Risk of failure in dual therapy versus triple therapy in naïve #HIV-patients: a systematic review and meta-analysis

Several attempts have been made to test different drug-sparing strategies to reduce the drug-burden and drug-related toxicities.. ..Fourteen studies were included, allowing a meta-analysis on 5,205 patients. The meta-analysis performed on studies that presented data at 48 weeks showed that the relative risk (RR) of treatment failure (TF) (RR>1 favoring triple therapy) in 10 studies was 1.20 (95%CI: 0.91-1.59, I 2: 49.2%); the RR of … Continue reading Risk of failure in dual therapy versus triple therapy in naïve #HIV-patients: a systematic review and meta-analysis

#Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study

Obesity shortens life expectancy. Bariatric surgery is known to reduce the long-term relative risk of death, but its effect on life expectancy is unclear.. ..In total, 2007 and 2040 patients were included in the surgery group and the control group, respectively, and 1135 participants were included in the reference cohort. At the time of the analysis (December 31, 2018), the median duration of follow-up for … Continue reading #Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study

Characteristics of Recurrent Ischemic #Stroke After Embolic Stroke of Undetermined Source Secondary Analysis of a Randomized Clinical Trial

The concept of embolic stroke of undetermined source (ESUS) unifies a subgroup of cryptogenic strokes based on neuroimaging, a defined minimum set of diagnostic tests, and exclusion of certain causes. Despite an annual stroke recurrence rate of 5%, little is known about the etiology underlying recurrent stroke after ESUS.. ..A total of 309 patients (205 men [66%]; mean [SD] age, 68 [10] years) had ischemic … Continue reading Characteristics of Recurrent Ischemic #Stroke After Embolic Stroke of Undetermined Source Secondary Analysis of a Randomized Clinical Trial

A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

Acupuncture techniques have been in existence for centuries, with roots tied to Eastern Asian medicine. Ease of application, low cost, and minimal side effects make traditional acupuncture a perioperative modality that has been linked to decreased morbidity and mortality in patients undergoing surgical procedures and anesthesia (1). In the United States, in light of the opioid epidemic, there is a strong need to decrease perioperative … Continue reading A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

Predictive Value of Initial #CT scan for Various Adverse Outcomes in Patients with #COVID-19 #Pneumonia

..This study investigates the predictive value of CT severity score (CSS) for length-of-stay (LOS) in hospital, initial disease severity, ICU admission, intubation, and mortality ..Total of 121 patients (60±16 years), including 54 women and 67 men, with positive RT-PCR tests were enrolled. We found a significant but weak correlation between CSS and qSOFA, as a measure of disease severity (r: 0.261, p= 0.003). No significant … Continue reading Predictive Value of Initial #CT scan for Various Adverse Outcomes in Patients with #COVID-19 #Pneumonia

What is the best way of delivering virtual #nature for improving mood?: An experimental comparison of high definition TV, 360º video, and computer generated virtual reality

Exposure to ‘real’ nature can increase positive affect and decrease negative affect, but direct access is not always possible, e.g. for people in health/care settings who often experience chronic boredom. In these settings ‘virtual’ forms of nature may also have mood-related benefits (e.g. reducing boredom) but it has been difficult to separate effects of nature content from those of delivery mode. The present laboratory-based study … Continue reading What is the best way of delivering virtual #nature for improving mood?: An experimental comparison of high definition TV, 360º video, and computer generated virtual reality

Association Between #Epidural Analgesia During Labor and Risk of #Autism Spectrum Disorders in Offspring

Although the safety of labor epidural analgesia (LEA) for neonates has been well documented, the long-term health effects of LEA on offspring remain to be investigated… ..Among the cohort of 147 895 singleton children (74 425 boys [50.3%]; mean [SD] gestational age at delivery, 38.9 [1.5] weeks), 109 719 (74.2%) were exposed to maternal LEA. Fever during labor was observed in 13 055 mothers (11.9%) in the LEA group … Continue reading Association Between #Epidural Analgesia During Labor and Risk of #Autism Spectrum Disorders in Offspring

Comparative evaluation of topical diclofenac sodium vs topical Ibuprofen in the treatment of #seborrheic keratosis.

In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis. One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily for 8 weeks. Adobe photoshop CS6 was used to measure the … Continue reading Comparative evaluation of topical diclofenac sodium vs topical Ibuprofen in the treatment of #seborrheic keratosis.

#Remdesivir for the Treatment of #Covid-19 — Final Report

Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious.. ..A total of 1062 patients underwent randomization (with 541 assigned to remdesivir and 521 to placebo). Those who received remdesivir had a median recovery time of 10 days (95% confidence interval [CI], 9 to 11), as compared with 15 days … Continue reading #Remdesivir for the Treatment of #Covid-19 — Final Report

Contamination and washing of cloth #masks and risk of infection among hospital health workers in Vietnam: a post hoc analysis of a randomised controlled trial

In a previous randomised controlled trial (RCT) in hospital healthcare workers (HCWs), cloth masks resulted in a higher risk of respiratory infections compared with medical masks. This was the only published RCT of cloth masks at the time of the COVID-19 pandemic.. ..Viral contamination with rhinovirus was identified on both used medical and cloth masks. Most HCW (77% of daily washing) self-washed their masks by … Continue reading Contamination and washing of cloth #masks and risk of infection among hospital health workers in Vietnam: a post hoc analysis of a randomised controlled trial

#Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress

Key points In humans, hypohydration attenuates sweat secretion and attenuates whole‐body heat loss, probably to mitigate further fluid losses and thereby support blood pressure regulation. Recently, however, we demonstrated that the hypohydration‐mediated reduction in net whole‐body heat exchange (evaporative heat loss – dry heat gain) was blunted in middle‐aged compared to younger men during moderate exercise in dry heat; albeit, the underpinning mechanisms could not … Continue reading #Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress

The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults

The triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD. ..The TyG index was significantly correlated with the severity of hepatic steatosis and the presence of liver fibrosis in patients with NAFLD. TyG quartile values … Continue reading The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults