#COVID-19 Pandemic: A Wake-Up Call for Clean #Air

..Since its identification in Wuhan, China, coronavirus disease 2019 (COVID-19) has infected more than 104 million and killed over 2.2 million people worldwide (1). Recent studies of air pollution and COVID-19 cases and mortality in diverse international settings add convincingly to a large body of evidence showing that exposure to air pollution exacerbates viral respiratory infections and consequently widens health disparities. Meanwhile, the global lockdown … Continue reading #COVID-19 Pandemic: A Wake-Up Call for Clean #Air

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Trial of #Psilocybin versus #Escitalopram for Depression

Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking. METHODS In a phase 2, double-blind, randomized, controlled trial involving patients with long-standing, moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, a selective serotonin-reuptake inhibitor, over a 6-week period. Patients were assigned in a 1:1 ratio to receive two separate doses of 25 mg of psilocybin 3 … Continue reading Trial of #Psilocybin versus #Escitalopram for Depression

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#Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis

Gastric cancer (GC) is the fifth diagnosed cancer worldwide and the third leading cause of death for cancer. Recent reports suggest that metabolic syndrome (MetS) has a role in etiology, progression or prognosis on GC. The aim of this study is to systematically review the evidence on the association between MetS and GC risk and prognosis. Methods Literature search was performed using the electronic databases … Continue reading #Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis

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Neurocognitive processing efficiency for discriminating human non-alarm rather than alarm scream calls

Across many species, scream calls signal the affective significance of events to other agents. Scream calls were often thought to be of generic alarming and fearful nature, to signal potential threats, with instantaneous, involuntary, and accurate recognition by perceivers. However, scream calls are more diverse in their affective signaling nature than being limited to fearfully alarming a threat, and thus the broader sociobiological relevance of … Continue reading Neurocognitive processing efficiency for discriminating human non-alarm rather than alarm scream calls

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Obstructive Sleep #Apnea as a Risk Factor for Intracerebral #Hemorrhage

To determine whether obstructive sleep apnea (OSA) is associated with intracerebral hemorrhage (ICH) risk, we assessed premorbid OSA exposure of patients with nontraumatic ICH and matched controls. Methods: Ethnic/Racial Variations of Intracerebral Hemorrhage is a multicenter, case-control study evaluating risk factors for ICH that recruited 3000 cases with ICH and 3000 controls. OSA status was ascertained using the Berlin Questionnaire as a surrogate for premorbid … Continue reading Obstructive Sleep #Apnea as a Risk Factor for Intracerebral #Hemorrhage

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#Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review

This review aimed to summarize the evidence on the risk of thromboembolism associated with carotid and aortic atherosclerosis in patients with AF, and the potential impact of their inclusion in current stroke risk stratification scores. Methods MEDLINE, Web of Science and EMBASE were systematically searched to identify all published studies providing relevant data through 28 February 2021. Results We identified 10 eligible studies. There was … Continue reading #Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review

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#Income robustly predicts self-regard #emotions

There is robust evidence that higher income makes people evaluate their lives more favorably, but there is no consistent evidence on whether it makes people feel better. Analyzing data from five large surveys spanning 162 countries, we predicted and found the most comprehensive evidence to date that income reliably predicted greater positive self-regard emotions (e.g., pride) and lower negative self-regard emotions (e.g., anxiety). In contrast, … Continue reading #Income robustly predicts self-regard #emotions

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The #COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal #Antibodies for the Treatment of COVID-19

The COVID-19 Treatment Guidelines Panel (the Panel) recommends using one of the following combination anti-SARS-CoV-2 monoclonal antibodies to treat outpatients with mild to moderate COVID-19 who are at high risk of clinical progression, as defined by the Emergency Use Authorization (EUA) criteria (listed in alphabetical order): Bamlanivimab 700 mg plus etesevimab 1,400 mg (AIIa); or Casirivimab 1,200 mg plus imdevimab 1,200 mg (AIIa). Treatment should … Continue reading The #COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal #Antibodies for the Treatment of COVID-19

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Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder

Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine on cognitive function in these disorders is not well understood. To address this gap, we examined the effect of a single dose of IV ketamine on cognition in individuals with MDD and/or PTSD relative to healthy controls … Continue reading Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder

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Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults

Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. Research Question Does a single high-dose (540,000 IU) enteral treatment of vitamin D3 given shortly after hospital admission in vitamin D deficient, critically-ill patients improve long-term global cognition or executive function? Study Design and Methods This study evaluated long-term cognitive outcomes among patients enrolled in a multicenter, blinded, randomized … Continue reading Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults

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Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for #Helicobacter pylori Infection: a Network Meta-Analysis.

A number of double, triple and quadruple therapies have been proposed as first line H. pylori infection empiric treatments. However, knowledge of their worldwide and regional comparative efficacy is lacking. We examined the comparative effectiveness of all empirically used first line regimens tested against standard triple treatment, using a network meta-analysis (NWM) of published RCTs. METHODS Data extracted from eligible RCTs were entered into a … Continue reading Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for #Helicobacter pylori Infection: a Network Meta-Analysis.

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6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records

Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis. Methods For this retrospective cohort study and time-to-event analysis, we used data … Continue reading 6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records

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