The ESC/EACTS myocardial revascularization guidelines recently standardized the definition of patients at high ischemic risk (HIR). However, the ability of ESC/EACTS-HIR criteria to stratify ischemic and bleeding risk in a contemporary real-world East Asian cohort remains unexplored. Methods: A total of 10,167 consecutive patients undergoing PCI from prospective Fuwai PCI Registry (January 2013 to December… Continue reading Prognostic and Practical Validation of ESC/EACTS High #Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary #PCI Patients
Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. MethodsSALVE grade was described by semiquantitative scores for steatosis, activity (hepatocellular injury and lobular neutrophils) and cholestasis. The… Continue reading Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
First case of postmortem study in a patient vaccinated against #SARS-CoV-2
Highlights•We report on a patient with a single dose of vaccine against SARS-CoV-2. •He developed relevant serum titer levels but died 4 weeks later. •By postmortem molecular mapping, we found viral RNA in nearly all organs examined. •However, we did not observe any characteristic morphological features of COVID-19. •Immunogenicity might be elicited, while sterile immunity… Continue reading First case of postmortem study in a patient vaccinated against #SARS-CoV-2
Magnetic Interference on #Cardiac Implantable Electronic Devices From Apple #iPhone MagSafe Technology
Magnet wireless charging is being utilized increasingly in current generation smartphones. Apple's MagSafe is a proprietary wireless charging technology with an array of magnets that has the capacity to generate magnet fieldstrength >50 gauss (G). We hypothesize that there is clinically significant magnet interference caused by Apple's MagSafe technology on cardiac implantable electronic devices (CIED).… Continue reading Magnetic Interference on #Cardiac Implantable Electronic Devices From Apple #iPhone MagSafe Technology
Human #immune system adaptations to simulated #microgravity revealed by single-cell mass cytometry
Exposure to microgravity (µG) during space flights produces a state of immunosuppression, leading to increased viral shedding, which could interfere with long term missions. However, the cellular mechanisms that underlie the immunosuppressive effects of µG are ill-defined. A deep understanding of human immune adaptations to µG is a necessary first step to design data-driven interventions… Continue reading Human #immune system adaptations to simulated #microgravity revealed by single-cell mass cytometry
Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
Readmission and mortality are the most common and often combined endpoints in acute heart failure (AHF) trials, but an association between these two outcomes is poorly investigated. The aim of this study was to determine whether unplanned readmission is associated with a greater subsequent risk of death in patients with acute dyspnoea due to cardiac… Continue reading Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
#Zinc drives #vasorelaxation by acting in sensory nerves, endothelium and smooth muscle
Zinc, an abundant transition metal, serves as a signalling molecule in several biological systems. Zinc transporters are genetically associated with cardiovascular diseases but the function of zinc in vascular tone regulation is unknown. We found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane.… Continue reading #Zinc drives #vasorelaxation by acting in sensory nerves, endothelium and smooth muscle
Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for #anxiety, #obsessive-compulsive, and #stress disorders: A 3-level network meta-analysis
Anxiety, obsessive-compulsive, and stress-related disorders frequently co-occur, and patients often present symptoms of several domains. Treatment involves the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), but data on comparative efficacy and acceptability are lacking. We aimed to compare the efficacy of SSRIs, SNRIs, and placebo in multiple symptom… Continue reading Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for #anxiety, #obsessive-compulsive, and #stress disorders: A 3-level network meta-analysis
Prevalence of increased #transaminases and its association with sex, age, and #metabolic parameters in children and adolescents wit7h obesity – a nationwide cross-sectional cohort study
Childhood obesity increases the risk of non-alcoholic fatty liver disease marked by elevated alanine aminotransferase (ALT). This study investigated the prevalence of increased ALT in children and adolescents with obesity, and its associations with sex, age, degree of obesity, and metabolic parameters. MethodsIndividuals between 5 and 17.99 years of age enrolled in the Swedish Childhood Obesity… Continue reading Prevalence of increased #transaminases and its association with sex, age, and #metabolic parameters in children and adolescents wit7h obesity – a nationwide cross-sectional cohort study
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