Laughing gas improves depressionAbout one-third of individuals suffering from depression are at risk for treatment resistance. Whereas inhaled 50% nitrous oxide has early antidepressant effects on individuals with treatment-resistant major depression (TRMD), adverse effects can occur at this concentration. In this phase 2 clinical trial, Nagele et al. studied the effects of a single 1-hour… Continue reading A phase 2 trial of inhaled #nitrous oxide for treatment-resistant major #depression
#Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis dysregulation observed in stress-related psychiatric disorders. In this study, we show that FK506-binding protein 51 (FKBP5) plays a critical role in fine-tuning MR:GR balance in the… Continue reading #Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5
#Thyroid Hormone Therapy and Incident #Stroke
Stroke is a leading cause of death and disability and there is a need to identify modifiable risk factors. ObjectiveDetermine the relationship between thyroid hormone treatment intensity and incidence of atrial fibrillation and stroke. DesignRetrospective cohort study using data from the Veterans Health Administration between 2004 and 2017, with a median follow-up of 59 months.… Continue reading #Thyroid Hormone Therapy and Incident #Stroke
Effect of #bariatric surgery on ischemic #stroke risk
Bariatric surgery has demonstrated improvements in cardiovascular health. The effect on ischemic stroke risk remains unclear. The goal of this study was to compare the risk of stroke among bariatric surgery patients versus controls. MethodsUsing Mariner, a national all-payer claims database, we identified patients with BMI > 40, or BMI > 35 with qualifying comorbidities… Continue reading Effect of #bariatric surgery on ischemic #stroke risk
Factors associated with #eating performance in older adults with #dementia in long-term care facilities: a cross-sectional study
The purpose of this study was to investigate factors influencing eating performance in older adults with dementia (OAWDs) in long-term care (LTC) facilities. MethodsThis cross-sectional study examined risk factors for compromised eating performance by comparing both independent and dependent older adults with dementia. The study participants were 117 OAWDs in LTC facilities in South Korea.… Continue reading Factors associated with #eating performance in older adults with #dementia in long-term care facilities: a cross-sectional study
Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
Highlights•n-3 and n-6 PUFAs preferentially accumulate in lipid droplets of acidic cancer cells •Excess LC-PUFAs undergo peroxidation and induce ferroptosis in acidic cancer cells •DGAT inhibitors prevent the formation of lipid droplets and promote ferroptosis •DGATi enhance the tumor growth inhibitory effects of dietary n-3 LC-PUFAs in mice SummaryTumor acidosis promotes disease progression through a… Continue reading Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
#Aggressive incidents in #psychiatric hospitals on #heat days
This study explores the relationship between temperature and the number of aggressive incidents and coercive interventions in the years 2007–2019 in six psychiatric hospitals in the south of the Germany with a total of 1007 beds. The number of aggressive incidents among 164 435 admissions was significantly higher on ‘heat days’ (≥30°C). Furthermore, there was… Continue reading #Aggressive incidents in #psychiatric hospitals on #heat days
Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy… Continue reading Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Effect of #meteorological factors and air #pollutants on #fractures: a nationwide population-based ecological study
To determine the association of meteorological factors and air pollutants (MFAPs) with fracture and to estimate the effect size/time lag. Design This is a nationwide population-based ecological study from 2008 to 2017. Setting Eight large metropolitan areas in Korea. Participants Of 8 093 820 patients with fractures reported in the Korea National Health Insurance database, 2 129 955 were… Continue reading Effect of #meteorological factors and air #pollutants on #fractures: a nationwide population-based ecological study
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