This study explores the relationship between temperature and the number of aggressive incidents and coercive interventions in the years 2007–2019 in six psychiatric hospitals in the south of the Germany with a total of 1007 beds. The number of aggressive incidents among 164 435 admissions was significantly higher on ‘heat days’ (≥30°C). Furthermore, there was… Continue reading #Aggressive incidents in #psychiatric hospitals on #heat days
Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy… Continue reading Reduced adaptation of glutamatergic #stress response is associated with #pessimistic expectations in #depression
Effect of #meteorological factors and air #pollutants on #fractures: a nationwide population-based ecological study
To determine the association of meteorological factors and air pollutants (MFAPs) with fracture and to estimate the effect size/time lag. Design This is a nationwide population-based ecological study from 2008 to 2017. Setting Eight large metropolitan areas in Korea. Participants Of 8 093 820 patients with fractures reported in the Korea National Health Insurance database, 2 129 955 were… Continue reading Effect of #meteorological factors and air #pollutants on #fractures: a nationwide population-based ecological study
Prognostic and Practical Validation of ESC/EACTS High #Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary #PCI Patients
The ESC/EACTS myocardial revascularization guidelines recently standardized the definition of patients at high ischemic risk (HIR). However, the ability of ESC/EACTS-HIR criteria to stratify ischemic and bleeding risk in a contemporary real-world East Asian cohort remains unexplored. Methods: A total of 10,167 consecutive patients undergoing PCI from prospective Fuwai PCI Registry (January 2013 to December… Continue reading Prognostic and Practical Validation of ESC/EACTS High #Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary #PCI Patients
Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its prognostic utility in a multinational cohort of 445 patients. MethodsSALVE grade was described by semiquantitative scores for steatosis, activity (hepatocellular injury and lobular neutrophils) and cholestasis. The… Continue reading Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
First case of postmortem study in a patient vaccinated against #SARS-CoV-2
Highlights•We report on a patient with a single dose of vaccine against SARS-CoV-2. •He developed relevant serum titer levels but died 4 weeks later. •By postmortem molecular mapping, we found viral RNA in nearly all organs examined. •However, we did not observe any characteristic morphological features of COVID-19. •Immunogenicity might be elicited, while sterile immunity… Continue reading First case of postmortem study in a patient vaccinated against #SARS-CoV-2
Magnetic Interference on #Cardiac Implantable Electronic Devices From Apple #iPhone MagSafe Technology
Magnet wireless charging is being utilized increasingly in current generation smartphones. Apple's MagSafe is a proprietary wireless charging technology with an array of magnets that has the capacity to generate magnet fieldstrength >50 gauss (G). We hypothesize that there is clinically significant magnet interference caused by Apple's MagSafe technology on cardiac implantable electronic devices (CIED).… Continue reading Magnetic Interference on #Cardiac Implantable Electronic Devices From Apple #iPhone MagSafe Technology
Human #immune system adaptations to simulated #microgravity revealed by single-cell mass cytometry
Exposure to microgravity (µG) during space flights produces a state of immunosuppression, leading to increased viral shedding, which could interfere with long term missions. However, the cellular mechanisms that underlie the immunosuppressive effects of µG are ill-defined. A deep understanding of human immune adaptations to µG is a necessary first step to design data-driven interventions… Continue reading Human #immune system adaptations to simulated #microgravity revealed by single-cell mass cytometry
Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
Readmission and mortality are the most common and often combined endpoints in acute heart failure (AHF) trials, but an association between these two outcomes is poorly investigated. The aim of this study was to determine whether unplanned readmission is associated with a greater subsequent risk of death in patients with acute dyspnoea due to cardiac… Continue reading Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
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