•A processed-foods diet (PD) impaired learning and memory in aged male rats. •PD increased inflammatory genes in the hippocampus and amygdala of aged rats. •DHA supplementation prevented memory deficits in PD-fed aged rats. •DHA supplementation ameliorated increases in inflammatory gene expression. •PD consumption led to increased weight gain in young and aged rats. AbstractThe consumption… Continue reading Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
Statins may be protective in SARS-CoV-2 infection. The aim of this study was to evaluate the effect of in-hospital statin use on 28-day mortality and ICU admission among patients with SARS-CoV-2 stratified into 4 groups: those who used statins prior to hospitalization (continued, discontinued) and those who did not (newly initiated, never). MethodsIn a cohort… Continue reading Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
People with mental disorders and intellectual disabilities experience excess mortality compared with the general population. The impact of COVID-19 on exacerbating this, and in widening ethnic inequalities, is unclear. METHODSProspective data (N=167,122) from a large mental healthcare provider in London, UK, with deaths from 2019 to 2020, used to assess age- and gender-standardised mortality ratios… Continue reading All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
Effect of Transcranial Near-Infrared #Light 1068 nm Upon #Memory Performance in Aging Healthy Individuals: A Pilot Study
We present a pilot study of near-infrared (NIR) 1068 nm transcranial photobiomodulation therapy (PBM-T). Impact upon motor function, memory, and processing speed in healthy individuals, older than 45 years of age, was evaluated. Methods: PBM-T was performed at home using a transcranial phototherapy device, a helmet that comprised 14 air cooled light emitting diode panel arrays,… Continue reading Effect of Transcranial Near-Infrared #Light 1068 nm Upon #Memory Performance in Aging Healthy Individuals: A Pilot Study
Incidence Rates and Predictors of Microvascular and Macrovascular Complications in Patients with Type 2 #Diabetes: Results from the Longitudinal Global DISCOVER Study
In a global prospective study of patients with relatively early-stage diabetes, microvascular and macrovascular complications were common and were associated with increased risk of subsequent hospitalization and death. •The strongest predictor of incident complications was the known atherosclerosis or heart failure at enrollment. •Poor glucose control and smoking were also associated with increased risk of… Continue reading Incidence Rates and Predictors of Microvascular and Macrovascular Complications in Patients with Type 2 #Diabetes: Results from the Longitudinal Global DISCOVER Study
#Heat stress and PPE during #COVID-19: impact on healthcare workers’ performance, safety and well-being in NHS settings
Personal protective equipment (PPE) can potentiate heat stress, which may have a negative impact on the wearer's performance, safety and well-being. In view of this, a survey was distributed to healthcare workers (HCWs) required to wear PPE during the coronavirus disease 2019 pandemic in the UK to evaluate perceived levels of heat stress and its… Continue reading #Heat stress and PPE during #COVID-19: impact on healthcare workers’ performance, safety and well-being in NHS settings
Visit-to-visit fasting blood #glucose variability and lifetime risk of #cardiovascular disease: a prospective study
Previous studies suggested an adverse association between higher fasting blood glucose (FBG) variability and cardiovascular disease (CVD). Lifetime risk provides an absolute risk assessment during the remainder of an individual’s life. However, the association between FBG variability and the lifetime risk of CVD is uncertain. ObjectiveWe aimed to investigate the effect of the visit-to-visit FBG… Continue reading Visit-to-visit fasting blood #glucose variability and lifetime risk of #cardiovascular disease: a prospective study
A microRNA signature that correlates with cognition and is a target against #cognitive decline
While some individuals age without pathological memory impairments, others develop age-associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal… Continue reading A microRNA signature that correlates with cognition and is a target against #cognitive decline
Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
Higher fracture risk in White versus Black women is partly explained by lower BMD and worse bone microarchitecture in White women. However, whether rates of decline in bone density, microarchitecture and strength differ between postmenopausal Black and White women is unknown. Further, factors that influence rates of age-related bone microarchitecture deterioration remain ill-defined. Thus, over… Continue reading Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
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