The intestinal microbiome releases a plethora of small molecules. Here, we show that the Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice and elderly people, whereas Ruminococcaceae phages, belonging to the Myoviridae family, are reduced. Young mice orally administered IAA show cognitive decline, whereas Myoviridae phage administration reduces IAA levels. Mechanistically, IAA promotes apoptosis… Continue reading Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death
Burnout in emergency medicine professionals after 2 years of the COVID-19 pandemic: a threat to the healthcare system?
AbstractBackground: Burnout is a common problem among healthcare professionals (HCPs), in particular young doctors and nurses working in emergency medical services. The coronavirus disease 2019 (COVID-19) pandemic has generated a substantial increase in the workload of those working in front-line services, and there is evidence of physical and mental distress among professionals that may have… Continue reading Burnout in emergency medicine professionals after 2 years of the COVID-19 pandemic: a threat to the healthcare system?
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals with Anorexia Nervosa – A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
BackgroundThe pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in grey matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy controls. Recent weight regain before scanning may explain some of this… Continue reading Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals with Anorexia Nervosa – A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
Adverse effects of COVID-19 vaccines and measures to prevent them
Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. According to European Medicines Agency recommendations, frequent COVID-19… Continue reading Adverse effects of COVID-19 vaccines and measures to prevent them
Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
Objectives Asthma is one of the greatest health burdens, yet contributors to asthma symptom trajectories are understudied in Australian children. We aimed to assess the trajectories of asthma symptom and their associations with several family environmental factors during the childhood period in Australia. Design Secondary analysis from a cross-sequential cohort study. Setting Nationwide representative data… Continue reading Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort study
A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phenome-wide association study (MR-PheWAS) using clinical and genetic data from a national healthcare system biobank. Methods and findingsAnalyses were performed using data from… Continue reading A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
May 2022 : Peculiar Evolution of the Monkeypox Virus Genomes
We compare the evolution of 14 monkeypox virus genomes til that of May 2022 that is currently spreading across humans in numerous countries outside Africa. Our aim was to discover mutations or other viral evolutions (recombination) that may explain the sudden impact of this very low-level circulating epidemic or alert on a potential peculiar pathogenic… Continue reading May 2022 : Peculiar Evolution of the Monkeypox Virus Genomes
Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts
BackgroundAlthough 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality.MethodsIn this meta-analysis, we identified studies investigating the effect of daily step count on all-cause mortality in adults… Continue reading Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts
1,287,595 Injuries Reported After COVID Shots, Vaccine Injury Compensation Programs ‘Overwhelmed’
The Centers for Disease Control and Prevention (CDC) today released new data showing a total of 1,287,595 reports of adverse events following COVID-19 vaccines were submitted between Dec. 14, 2020, and May 27, 2022, to the Vaccine Adverse Event Reporting System (VAERS). That’s an increase of 9,615 adverse events over the previous week. VAERS is… Continue reading 1,287,595 Injuries Reported After COVID Shots, Vaccine Injury Compensation Programs ‘Overwhelmed’
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