In recent months, multiple lineages of the omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged,1 with subvariants BA.1 and BA.2 showing substantial escape from neutralizing antibodies.2-5 Subvariant BA.2.12.1 is now the dominant strain in the United States, and BA.4 and BA.5 are dominant in South Africa (Figure 1A). Subvariants BA.4… Continue reading Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5
Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants
Immune function and sensitivity to pain are closely related, but the association between early life inflammation and sensory nervous system development is poorly understood—especially in humans. Here, in term-born infants, we measure brain activity and reflex withdrawal activity (using EEG and EMG) and behavioural and physiological activity (using the PIPP-R score) to assess the impact… Continue reading Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants
Predictors of hospital readmission after fractures: One-year follow-up study
OBJECTIVE: Identify the incidence and predictive factors for readmissions of elderly hospitalized with fractures.METHOD: Prospective cohort study on 376 elderly people from a trauma referral large hospital in central Brazil. Data were collected from medical records of elderly people with radiological diagnosis of fractures. Readmission that occurs up to one year after the first discharge… Continue reading Predictors of hospital readmission after fractures: One-year follow-up study
Soil and water pollution and human health: what should cardiologists worry about?
Healthy soil is foundational to human health. Healthy soil is needed to grow crops, provides food, and sustains populations. It supports diverse ecosystems and critical ecological services such as pollination. It stores water and prevents floods. It captures carbon and slows global climate change. Soil pollution is a great and growing threat to human health.… Continue reading Soil and water pollution and human health: what should cardiologists worry about?
Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy
Background and AimsThe stroma in pancreatic ductal adenocarcinoma (PDAC) contributes to its immunosuppressive nature and therapeutic resistance. Herein we sought to modify signaling and enhance immunotherapy efficacy by targeting multiple stromal components through both intracellular and extracellular mechanisms.MethodsA murine liver metastasis syngeneic model of PDAC was treated with focal adhesion kinase inhibitor (FAKi), anti-PD-1 antibody… Continue reading Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy
Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial
AbstractBackgroundExcess visceral adiposity is associated with increased risk of cardiometabolic disorders. Short‐term well‐controlled clinical trials suggest that regular avocado consumption favorably affects body weight, visceral adiposity, and satiety.Methods and ResultsThe HAT Trial (Habitual Diet and Avocado Trial) was a multicenter, randomized, controlled parallel‐arm trial designed to test whether consuming 1 large avocado per day for… Continue reading Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial
Duration of immune protection of SARS-CoV-2 natural infection against reinfection in Qatar
BACKGROUND The future of the SARS-CoV-2 pandemic hinges on virus evolution and duration of immune protection of natural infection against reinfection. We investigated duration of protection afforded by natural infection, the effect of viral immune evasion on duration of protection, and protection against severe reinfection, in Qatar, between February 28, 2020 and June 5, 2022.… Continue reading Duration of immune protection of SARS-CoV-2 natural infection against reinfection in Qatar
Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder
BackgroundPrevious studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum disorder (ASD). The aim of this article was to investigate whether allergic disorders are associated with ADHD/ASD in a large cohort of pediatric patients. MethodsA retrospective study using the pediatric (0–18 year) database (ICD-9-CM codes) of Clalit Health… Continue reading Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder
I Hear My Voice; Therefore I Spoke: The Sense of Agency Over Speech Is Enhanced by Hearing One’s Own VoiceHear My Voice; Therefore I Spoke: The Sense of Agency Over Speech Is Enhanced by Hearing One’s Own Voice
The subjective experience of causing an action is known as the sense of agency. Dysfunctional sense of agency over speech has been suggested as a cause of auditory hallucinations. However, agency over speech has not been extensively characterized in previous empirical studies. Here, we manipulated self-voice identity, an indicator of self, embedded in the acoustic… Continue reading I Hear My Voice; Therefore I Spoke: The Sense of Agency Over Speech Is Enhanced by Hearing One’s Own VoiceHear My Voice; Therefore I Spoke: The Sense of Agency Over Speech Is Enhanced by Hearing One’s Own Voice
2 Medical News 