Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited. Objective: To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and… Continue reading #Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
Category: Psychiatry
Cross-sectional associations of schoolchildren’s #fruit and #vegetable consumption, and meal choices, with their mental well-being: a cross-sectional study
Poor mental well-being is a major issue for young people and is likely to have long-term negative consequences. The contribution of nutrition is underexplored. We, therefore, investigated the association between dietary choices and mental well-being among schoolchildren. Methods Data from 7570 secondary school and 1253 primary school children in the Norfolk Children and Young People… Continue reading Cross-sectional associations of schoolchildren’s #fruit and #vegetable consumption, and meal choices, with their mental well-being: a cross-sectional study
Incident Major #Depressive Disorder Predicted by Three Measures of Insulin #Resistance: A Dutch Cohort Study
Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the disorder. An important first step in this process is identifying risk factors for the incidence of major depression. There is accumulating biological evidence linking insulin resistance, another… Continue reading Incident Major #Depressive Disorder Predicted by Three Measures of Insulin #Resistance: A Dutch Cohort Study
Altered Composition of Gut #Microbiota in #Depression: A Systematic Review
Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify the alterations of the gut microbiota patterns in people with depression compared to healthy controls. A comprehensive literature search of human studies, published between January 2000 and June 2019, was… Continue reading Altered Composition of Gut #Microbiota in #Depression: A Systematic Review
Effect of #Zuranolone vs Placebo in Postpartum #DepressionA Randomized Clinical Trial
Postpartum depression (PPD) is one of the most common medicalcomplications during and after pregnancy, negatively affecting both mother and child.OBJECTIVE To demonstrate the efficacy and safety of zuranolone, a neuroactive steroidγ-aminobutyric acid receptor–positive allosteric modulator, in PPD. DESIGN, SETTING, AND PARTICIPANTS This phase 3, double-blind, randomized, outpatient,placebo-controlled clinical trial was conducted between January 2017 and… Continue reading Effect of #Zuranolone vs Placebo in Postpartum #DepressionA Randomized Clinical Trial
Pilot randomized controlled trial of a #hypnosis intervention for women with #bladder pain syndrome
To evaluate the feasibility and acceptability of a randomized controlled trial of a hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC) in women. MethodsWe conducted a parallel arm, non-blinded, pilot randomized controlled trial of standardized hypnosis sessions including a hypnosis web tool versus usual care in adult women with BPS/IC. Pilot study… Continue reading Pilot randomized controlled trial of a #hypnosis intervention for women with #bladder pain syndrome
Reinforcement learning links spontaneous cortical #dopamine impulses to reward
Extrasynaptic levels of dopamine in mouse cortex exhibit spontaneous impulses•Impulses are broadly distributed in amplitude and time, with a rate of about 0.01/s•Feedback was used to train mice to volitionally control their spontaneous impulses•Mice learned to reliably modulate dopamine impulses in order to receive a reward SummaryIn their pioneering study on dopamine release, Romo and… Continue reading Reinforcement learning links spontaneous cortical #dopamine impulses to reward
#Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Psilocybin ameliorates stress-related behavioral deficit in mice•Psilocybin increases spine density and spine size in frontal cortical pyramidal cells•Psilocybin-evoked structural remodeling is persistent for at least 1 month•The dendritic rewiring is accompanied by elevated excitatory neurotransmission SummaryPsilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural… Continue reading #Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
The effect of #depression status change on daily #cigarette smoking amount according to sex: an eleven-year follow up study of the Korea Welfare Panel Study
In the past decade, the Korean smoking rate has only decreased by 3%, despite several smoking control policies. There is a need for such policies to take smokers’ psychological characteristics into account. Depression is a well-known contributor to failed smoking cessation. This study aimed to examine the effect of smokers’ depression status changes on their… Continue reading The effect of #depression status change on daily #cigarette smoking amount according to sex: an eleven-year follow up study of the Korea Welfare Panel Study
