AbstractProinflammatory cytokines have been approved by the Food and Drug Administration for the treatment of metastatic melanoma and renal carcinoma. However, effective cytokine therapy requires high-dose infusions that can result in antidrug antibodies and/or systemic side effects that limit long-term benefits. To overcome these limitations, we developed a clinically translatable cytokine delivery platform composed of… Continue reading Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors
Category: Oncology
MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
MYC's role in promoting tumorigenesis is beyond doubt, but its function in the metastatic process is still controversial. Omomyc is a MYC dominant negative that has shown potent antitumor activity in multiple cancer cell lines and mouse models, regardless of their tissue of origin or driver mutations, by impacting on several of the hallmarks of… Continue reading MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
To examine the association of sedentary behavior with risk of ovarian cancer overall, by tumor subtype, and by participant characteristics in the Nurses’ Health Study (NHS) and NHSII. A total of 69,558 NHS (1992-2016) and 104,130 NHSII (1991-2015) participants were included in analysis who reported sitting time at home, work, and watching television, which included… Continue reading Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants
Following a vegetarian diet has become increasingly popular and some evidence suggests that being vegetarian may be associated with a lower risk of cancer overall. However, for specific cancer sites, the evidence is limited. Our aim was to assess the associations of vegetarian and non-vegetarian diets with risks of all cancer, colorectal cancer, postmenopausal breast… Continue reading Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants
Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial
Vitamin D insufficiency is associated with risk of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits with vitamin D supplementation is limited. ObjectivesTo investigate the effects of vitamin D3 supplementation on CVD and cancer incidence. DesignThe study was a 5-year randomized placebo-controlled trial among 2495 male participants ≥ 60 years and… Continue reading Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial
Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
BackgroundDietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. MethodsData on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during… Continue reading Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
Association of Daily Sitting Time and Leisure-Time Physical Activity With Survival Among US Cancer Survivors
Objective To examine the independent and joint associations of daily sitting time and leisure-time physical activity with mortality outcomes among cancer survivors. Design, Setting, and Participants A prospective cohort of a nationally representative sample of cancer survivors, age 40 years or older (n = 1535; weighted population, 14 002 666), from the US National Health and Nutrition Examination Survey… Continue reading Association of Daily Sitting Time and Leisure-Time Physical Activity With Survival Among US Cancer Survivors
COVID-19 Vaccination and Breakthrough Infections in Patients with Cancer
Highlights•Patients with cancer who develop breakthrough COVID-19 following full vaccination remain susceptible to severe outcomes.•Hematologic malignancies are over-represented among vaccinated patients with cancer who develop breakthrough COVID-19.•Vaccination of close contacts, masking, boosters, and social distancing are needed to protect patients with cancer. AbstractBackgroundVaccination is an important preventive health measure to protect against symptomatic and severe… Continue reading COVID-19 Vaccination and Breakthrough Infections in Patients with Cancer
Association of Metabolic Health and Central Obesity With the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study
Background:It is unknown whether the risk of thyroid cancer differs among metabolically healthy/unhealthy, normal-weight, or obese women. We aimed to assess the association of metabolic health and obesity with thyroid cancer risk. Methods:The Korean Genome and Epidemiology Study is a population-based prospective cohort study. Data were obtained from 173,343 participants (age {greater than or equal… Continue reading Association of Metabolic Health and Central Obesity With the Risk of Thyroid Cancer: Data from the Korean Genome and Epidemiology Study
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