Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent.Research question Are UPF associated with an increased risk of lung cancer, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)？Methods Data of participants in this study were collected from the Prostate, Lung, Colorectal and Ovarian (PLCO)… Continue reading Association between ultra-processed #food consumption and #lung #cancer risk: a population-based cohort study
Category: Oncology
Body #mass index and #breast cancer risk among #postmenopausal women with and without cardiometabolic diseases: Findings from two prospective cohort studies in Europe
BackgroundAdiposity, measured by body mass index (BMI), is a known risk factor for postmenopausal breast cancer. However, whether the association of BMI with breast cancer risk differs among women with and without cardiovascular diseases (CVDs) or type 2 diabetes (T2D) is uncertain.MethodsThis study used individual participant data from the European Prospective Investigation into Cancer and… Continue reading Body #mass index and #breast cancer risk among #postmenopausal women with and without cardiometabolic diseases: Findings from two prospective cohort studies in Europe
Structured #Exercise after Adjuvant Chemotherapy for #Colon #Cancer
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking.MethodsIn this phase 3, randomized trial conducted at 55 centers, we assigned patients with resected colon cancer who had completed adjuvant chemotherapy to participate in a structured exercise program (exercise group) or to receive health-education materials alone (health-education… Continue reading Structured #Exercise after Adjuvant Chemotherapy for #Colon #Cancer
Mammographic classification of interval breast cancers and #artificial intelligence performance
European studies suggest artificial intelligence (AI) can reduce interval breast cancers (IBCs). However, research on IBC classification and AI’s effectiveness in the U.S., particularly using digital breast tomosynthesis (DBT) and annual screening, is limited. We aimed to mammographically classify IBCs and assess AI performance using a 12-month screening interval.MethodsFrom digital mammography (DM) and DBT screening… Continue reading Mammographic classification of interval breast cancers and #artificial intelligence performance
Integrative analysis reveals therapeutic potential of #pyrvinium pamoate in #Merkel cell carcinoma
Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine cutaneous malignancy arising from either ultraviolet-induced mutagenesis or Merkel cell polyomavirus (MCPyV) integration. Despite extensive research, our understanding of the molecular mechanisms driving the transition from normal cells to MCC remains limited. To address this knowledge gap, we assessed the impact of inducible MCPyV T antigens on… Continue reading Integrative analysis reveals therapeutic potential of #pyrvinium pamoate in #Merkel cell carcinoma
Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
AbstractThe COVID-19 vaccine is a significant technological advancement with widespread global use. However, its effect on cancer immunity, particularly with repeated vac-cinations, remains unclear. We aimed to investigate the relationship between repeated vaccinations and pancreatic cancer (PC) prognosis. Additionally, we examined serum IgG4 levels, known to be an immune suppressor and increased with repeated vac-cinations.… Continue reading Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
#Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal #cancer
Diet, microbiome, inflammation and host genetics have been linked to colorectal cancer development; however, it is not clear whether and how these factors interact to promote carcinogenesis. Here we used Il10−/− mice colonized with bacteria previously associated with colorectal cancer: enterotoxigenic Bacteroides fragilis, Helicobacter hepaticus or colibactin-producing (polyketide synthase-positive (pks+)) Escherichia coli and fed either… Continue reading #Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal #cancer
#Aspirin prevents #metastasis by limiting platelet TXA2 suppression of T cell #immunity
Metastasis is the spread of cancer cells from primary tumours to distant organs and is the cause of 90% of cancer deaths globally1,2. Metastasizing cancer cells are uniquely vulnerable to immune attack, as they are initially deprived of the immunosuppressive microenvironment found within established tumours3. There is interest in therapeutically exploiting this immune vulnerability to… Continue reading #Aspirin prevents #metastasis by limiting platelet TXA2 suppression of T cell #immunity
Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
Evidence suggests a tumor-suppressive effect of the intake of yogurt, which typically contains Bifidobacterium. We hypothesized that long-term yogurt intake might be associated with colorectal cancer incidence differentially by tumor subgroups according to the amount of tissue Bifidobacterium. We utilized the prospective cohort incident-tumor biobank method and resources of two prospective cohort studies. Inverse probability… Continue reading Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
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