The associations between #trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for… Continue reading Serum elaidic acid concentration and risk of #dementia. The Hisayama study
Category: Neurology
Dietary #salt promotes cognitive impairment through tau phosphorylation
Dietary habits and vascular risk factors promote both #Alzheimer’s disease and cognitive impairment caused by vascular factors. Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protein and a hallmark of Alzheimer’s pathology, is also linked to vascular cognitive impairment. In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral… Continue reading Dietary #salt promotes cognitive impairment through tau phosphorylation
Regulation of #lifespan by #neural excitation and REST
..Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function. In Caenorhabditis elegans, neural excitation increases with age and inhibition of excitation globally, or in glutamatergic or cholinergic neurons, increases longevity. Furthermore,… Continue reading Regulation of #lifespan by #neural excitation and REST
Effects of #tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic #brain injury (CRASH-3): a randomised, placebo-controlled trial
Tranexamic acid reduces surgical bleeding and decreases mortality in patients with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury (TBI) and can cause brain herniation and death. We aimed to assess the effects of tranexamic acid in patients with TBI. The risk of head injury-related death reduced with tranexamic acid in patients… Continue reading Effects of #tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic #brain injury (CRASH-3): a randomised, placebo-controlled trial
Risk of Developing #Parkinson Disease in #Bipolar Disorder A Systematic Review and Meta-analysis
..Seven studies were eligible for inclusion and included 4 374 211 participants overall. A previous diagnosis of BD increased the likelihood of a subsequent diagnosis of idiopathic PD (odds ratio, 3.35; 95% CI, 2.00-5.60; I2 = 92%). A sensitivity analysis was performed by removing the studies that had a high risk of bias and also showed an increased risk… Continue reading Risk of Developing #Parkinson Disease in #Bipolar Disorder A Systematic Review and Meta-analysis
Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial
..exploring the effects of chair yoga (CY), compared to music intervention (MI) and chair-based exercise (CBE) in this population. Using a cluster randomized controlled trial (RCT), 3 community sites were randomly assigned 1:1:1 to CY, MI, or CBE. Participants attended twice-weekly 45-minute sessions for 12 weeks.. The CY group improved significantly in quality of life… Continue reading Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial
Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Results Anticoagulation with dabigatran prevented memory decline, cerebral hypoperfusion, and toxic fibrin deposition in the AD mouse brain. In addition, long-term dabigatran treatment significantly reduced the extent of amyloid plaques, oligomers, phagocytic microglia, and infiltrated T cells by 23.7%, 51.8%, 31.3%, and 32.2%, respectively. Dabigatran anticoagulation also prevented AD-related astrogliosis and pericyte alterations, and maintained… Continue reading Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Interplay of Objective #sleep Duration and Cardiovascular and #Cerebrovascular Diseases on Cause‐Specific Mortality
Cardiovascular and cerebrovascular diseases (CBVDs) and cancer are leading causes of death. Short sleep is a potential contributor to health; however, its role in predicting mortality associated with cardiometabolic risk factors (CMRs) and CBVD remains poorly understood. CMR was defined as stage 2 hypertension and/or type 2 diabetes mellitus on the basis of blood pressure and glucose levels… Continue reading Interplay of Objective #sleep Duration and Cardiovascular and #Cerebrovascular Diseases on Cause‐Specific Mortality
Risk of #rhabdomyolysis with #donepezil compared with rivastigmine or galantamine: a population-based cohort study
Donepezil, rivastigmine and galantamine are popular cholinesterase inhibitors used to manage the symptoms of #Alzheimer disease and other dementias; regulatory agencies in several countries warn about a possible risk of rhabdomyolysis.. ..The average age in our 2 groups was 81.1 years, and 61.4% of our population was female. Donepezil was associated with a higher risk… Continue reading Risk of #rhabdomyolysis with #donepezil compared with rivastigmine or galantamine: a population-based cohort study
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