Healthy #lifestyle and life #expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study

..Five low risk lifestyle factors: never smoking, body mass index 18.5-24.9, moderate to vigorous physical activity (โ‰ฅ30 minutes/day), moderate alcohol intake (women: 5-15 g/day; men 5-30 g/day), and a higher diet quality score (upper 40%). .. The life expectancy free of diabetes, cardiovascular diseases, and cancer at age 50 was 23.7 years (95% confidence interval 22.6 to 24.7) for women who adopted no low risk … Continue reading Healthy #lifestyle and life #expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study

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Regulation of #lifespan by #neural excitation and REST

..Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function. In Caenorhabditis elegans, neural excitation increases with age and inhibition of excitation globally, or in glutamatergic or cholinergic neurons, increases longevity. Furthermore, longevity is dynamically regulated by the excitatoryโ€“inhibitory balance of neural … Continue reading Regulation of #lifespan by #neural excitation and REST

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