Regulation of #lifespan by #neural excitation and REST

..Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function. In Caenorhabditis elegans, neural excitation increases with age and inhibition of excitation globally, or in glutamatergic or cholinergic neurons, increases longevity. Furthermore, longevity is dynamically regulated by the excitatoryโ€“inhibitory balance of neural … Continue reading Regulation of #lifespan by #neural excitation and REST

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