..The risk of myocardial infarction and ischemic stroke increased with higher hemoglobin concentration in both men and women. The HRs for myocardial infarction and ischemic stroke in men with hemoglobin concentration ≥ 17.5 g/dL were 3.52 (95% confidence interval [CI], 2.85–4.36) and 2.36 (95% CI, 1.63–3.43), respectively, compared to the reference group. The corresponding HRs for women with… Continue reading #Hemoglobin concentration and risk of arterial and venous #thrombosis in 1.5 million Swedish and Danish blood donors
Category: Neurology
Neurontin, Gralise, Horizant (#gabapentin) and Lyrica, Lyrica CR (#pregabalin): Drug Safety Communication – Serious Breathing Problems
..FDA is warning that serious breathing difficulties may occur in patients using gabapentin (Neurontin, Gralise, Horizant) or pregabalin (Lyrica, Lyrica CR) who have respiratory risk factors. These include the use of opioid pain medicines and other drugs that depress the central nervous system, and conditions such as chronic obstructive pulmonary disease that reduce lung function.… Continue reading Neurontin, Gralise, Horizant (#gabapentin) and Lyrica, Lyrica CR (#pregabalin): Drug Safety Communication – Serious Breathing Problems
Body #mass index, diet, physical inactivity, and the incidence of #dementia in 1 million UK women
..Fifteen years after the baseline survey, only 1% were lost to follow-up, and 89% remained alive with no detected dementia, of whom 18,695 had dementia detected later, at a mean age of 77 (SD 4) years. Dementia detection during years 15+ was associated with baseline obesity (BMI 30+ vs 20–24 kg/m2: RR 1.21, 95% confidence… Continue reading Body #mass index, diet, physical inactivity, and the incidence of #dementia in 1 million UK women
Low-Density #Lipoprotein Cholesterol and Risk of Hemorrhagic #stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies
..A previous meta-analysis of prospective studies published in 2013 showed that higher concentrations of LDL-C were associated with lower risk of hemorrhagic stroke. ..The results showed that a 10 mg/dL increase in LDL-C was associated with 3% lower risk of hemorrhagic stroke (pooled relative risk [RR] 0.97, 95% confidence interval [CI] 0.95–0.98). The association appeared… Continue reading Low-Density #Lipoprotein Cholesterol and Risk of Hemorrhagic #stroke: a Systematic Review and Dose-Response Meta-analysis of Prospective Studies
Boom Chack Boom—A multimethod investigation of motor inhibition in professional #drummers
Our hands are the primary means for motor interaction with the environment, and their neural organization is fundamentally asymmetric: While most individuals can perform easy motor tasks with two hands equally well, only very few individuals can perform complex fine motor tasks with both hands at a similar level of performance.. ..Our results show that… Continue reading Boom Chack Boom—A multimethod investigation of motor inhibition in professional #drummers
#Sleep duration, midday napping, and sleep quality and incident #stroke The Dongfeng-Tongji cohort
..Compared with sleeping 7 to <8 hours/night, those reporting longer sleep duration (≥9 hours/night) had a greater risk of total stroke (hazard ratio [HR] 1.23; 95% confidence interval [CI] 1.07–1.41), while shorter sleep (<6 hours/night) had no significant effect on stroke risk. The HR (95% CI) of total stroke was 1.25 (1.03–1.53) for midday napping… Continue reading #Sleep duration, midday napping, and sleep quality and incident #stroke The Dongfeng-Tongji cohort
Are symptoms of #insomnia in primary care associated with subsequent onset of #dementia? A matched retrospective case-control study
..We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care. ..We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities.… Continue reading Are symptoms of #insomnia in primary care associated with subsequent onset of #dementia? A matched retrospective case-control study
Extra virgin #olive oil improves synaptic activity, short‐term plasticity, #memory, and neuropathology in a tauopathy model
In recent years, increasing evidence has accumulated supporting the health benefits of extra virgin olive oil (EVOO). Previous studies showed that EVOO supplementation improves Alzheimer's disease (AD)‐like amyloidotic phenotype of transgenic mice.. ..At the end of the treatment, compared with control mice receiving EVOO displayed improved memory and cognition which was associated with increased basal… Continue reading Extra virgin #olive oil improves synaptic activity, short‐term plasticity, #memory, and neuropathology in a tauopathy model
#Cognitive Decline Over Time in Patients With Systolic #Heart Failure Insights From WARCEF
This study sought to characterize cognitive decline (CD) over time and its predictors in patients with systolic heart failure (HF) ..In logistic regression, CD was independently associated with higher baseline MMSE scores (odds ratio [OR]: 1.13; 95% confidence interval [CI]: 1.07 to 1.20]; p < 0.001), older age (OR: 1.37; 95% CI: 1.24 to 1.50;… Continue reading #Cognitive Decline Over Time in Patients With Systolic #Heart Failure Insights From WARCEF
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