The HOPE-3 trial (Heart Outcomes Prevention Evaluation–3) found that antihypertensive therapy combined with a statin reduced first stroke among people at intermediate cardiovascular risk. We report secondary analyses of stroke outcomes by stroke subtype, predictors, treatment effects in key subgroups. Methods:Using a 2-by-2 factorial design, 12 705 participants from 21 countries with vascular risk factors… Continue reading #Antihypertensives and #Statin Therapy for Primary #Stroke Prevention
Category: Neurology
The #overfitted brain: #Dreams evolved to assist generalization
Dreaming remains a mystery to neuroscience. While various hypotheses of why brains evolved nightly dreaming have been put forward, many of these are contradicted by the sparse, hallucinatory, and narrative nature of dreams, a nature that seems to lack any particular function. Recently, research on artificial neural networks has shown that during learning, such networks… Continue reading The #overfitted brain: #Dreams evolved to assist generalization
#Smoking is associated with impaired verbal learning and #memory performance in women more than men
Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating vascular disease risks. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific relationships between smoking and memory performance and… Continue reading #Smoking is associated with impaired verbal learning and #memory performance in women more than men
#Sarcopenia is independently associated with #parietal atrophy in older adults
Highlights•Sarcopenia was common in old adults living in a retirement community (46.1%). •Sarcopenia had moderate-severe global cortical, parietal and medial temporal atrophy. •Sarcopenia is significantly associated with parietal atrophy in older adults. •Age had a significant relationship with global cortical and medial temporal atrophy. AbstractIntroductionAs populations age, sarcopenia becomes a major health problem among adults… Continue reading #Sarcopenia is independently associated with #parietal atrophy in older adults
Colonization of the #Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
Protein conformational diseases are characterized by misfolding and toxic aggregation of metastable proteins, often culminating in neurodegeneration. Enteric bacteria influence the pathogenesis of neurodegenerative diseases; however, the complexity of the human microbiome hinders our understanding of how individual microbes influence these diseases. Disruption of host protein homeostasis, or proteostasis, affects the onset and progression of… Continue reading Colonization of the #Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD), we analyzed cross-sectional data from the German Longitudinal Cognitive Impairment and Dementia Study Method: The sample (n=512, mean age: 69.5±5.9 years) included 169 cognitively normal participants and subjects at higher AD risk (53 AD relatives,… Continue reading #Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
Task-Dependent Functional and Effective #Connectivity during Conceptual Processing
Conceptual knowledge is central to cognition. Previous neuroimaging research indicates that conceptual processing involves both modality-specific perceptual-motor areas and multimodal convergence zones. For example, our previous functional magnetic resonance imaging (fMRI) study revealed that both modality-specific and multimodal regions respond to sound and action features of concepts in a task-dependent fashion (Kuhnke P, Kiefer M,… Continue reading Task-Dependent Functional and Effective #Connectivity during Conceptual Processing
Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
In 2015, a patient in hospice with Alzheimer’s disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was observed. These improvements were so momentous that she was discharged from the hospice to a long-term care home. Based on this case, we conducted a… Continue reading Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
#Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort
Cognitive leisure activity, such as reading, playing mahjong or cards and computer use, is common among older adults in China. Previous studies suggest a negative correlation between cognitive leisure activity and cognitive impairment. However, the relationship between cognitive leisure activity and all-cause mortality has rarely been reported. ObjectivesThis study aims to explore the relationships between… Continue reading #Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort
2 Medical News 