Elevated renal flow pulsatility may contribute to the pathogenesis of chronic kidney disease (CKD). The purpose of this study was to investigate the associations among age, renal flow pulsatility, and CKD biomarkers in non-CKD adults and CKD patients. MethodsNon-CKD adults (n = 415) and CKD patients (n = 136) aged between 22 and 83 years underwent the renal blood flow… Continue reading #Renal hemodynamics across the adult lifespan: Relevance of #flow pulsatility to chronic kidney disease
Category: Nephrology
Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between depressive symptoms and rapid decline in kidney function in Chinese adults with normal kidney function. Design, setting, participants, & measurements A total of 4763 participants with eGFR≥60 ml/min per 1.73 m2 at baseline were enrolled from… Continue reading Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis
Coronavirus disease 2019 (COVID-19) is associated with higher morbidity and mortality in patients on maintenance hemodialysis. Patients on dialysis tend to have a reduced immune response to infection or vaccination. We aimed to assess, for the first time to the best of our knowledge, the humoral response following vaccination with the BNT162b2 vaccine in patients… Continue reading Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis
Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians
Antimicrobial overuse is a major health care issue that contributes to antibiotic resistance. Such overuse includes unnecessarily long durations of antibiotic therapy in patients with common bacterial infections, such as acute bronchitis with chronic obstructive pulmonary disease (COPD) exacerbation, community-acquired pneumonia (CAP), urinary tract infections (UTIs), and cellulitis. This article describes best practices for prescribing… Continue reading Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians
Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease
Adults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for recurrent CVD events following a myocardial infarction (MI). Methods We compared the risk for recurrent CVD events among US adults with health insurance who… Continue reading Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease
#Renal Failure is Associated With Increased Mortality and Hospital Utilization in Patients Admitted With Nonalcoholic #Steatohepatitis
We aimed to investigate the mortality and hospital utilization outcomes of hospitalized nonalcoholic steatohepatitis (NASH) patients with and without kidney failure in a nationwide cohort.. ..The overall sample included 7,135,090 patients. Among 6855 patients admitted for NASH, 598 or 8.7% had comorbid kidney failure. After multivariate regression analysis, NASH patients with renal failure had increased… Continue reading #Renal Failure is Associated With Increased Mortality and Hospital Utilization in Patients Admitted With Nonalcoholic #Steatohepatitis
Diagnosis-wide analysis of #COVID-19 complications: an exposure-crossover study
Many studies reporting coronavirus disease 2019 (COVID-19) complications have involved case series or small cohorts that could not establish a causal association with COVID-19 or provide risk estimates in different care settings. We sought to study all possible complications of COVID-19 to confirm previously reported complications and to identify potential complications not yet known.. ..Among… Continue reading Diagnosis-wide analysis of #COVID-19 complications: an exposure-crossover study
Comparison of #gabapentin and #doxepin in the management of #uremic pruritus: A randomized crossover clinical trial
Gabapentin and doxepin are well‐known treatments of uremic pruritus in hemodialysis patients but no head‐to‐head studies were conducted to date. The aim of this trial is to compare the efficacy and the tolerability of gabapentin and doxepin in the treatment of uremic pruritus in hemodialysis patients. A single‐blind crossover randomized trial was conducted that included… Continue reading Comparison of #gabapentin and #doxepin in the management of #uremic pruritus: A randomized crossover clinical trial
Risk Factor Control and #Cardiovascular Event Risk in People With Type 2 #Diabetes in Primary and Secondary Prevention Settings
To examine the association between the degree of risk factor control and cardiovascular disease (CVD) risk in type 2 diabetes and to assess if the presence of cardio-renal disease modifies these relationships. A retrospective cohort study using data from English practices from CPRD GOLD (Clinical Practice Research Datalink) and the SCI-Diabetes dataset (Scottish Care Information-Diabetes),… Continue reading Risk Factor Control and #Cardiovascular Event Risk in People With Type 2 #Diabetes in Primary and Secondary Prevention Settings
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