Low 25-OH serum vitamin D (VitD) is pervasive in older adults and linked to functional decline and progression of frailty. We have previously shown that chronic VitD insufficiency in “middle-aged” mice results in impaired anaerobic exercise capacity, decreased lean mass, and increased adiposity. Here, we examine if VitD insufficiency results in similar deficits and greater… Continue reading Vitamin #D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
Category: Gerontology
#Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress
Key points In humans, hypohydration attenuates sweat secretion and attenuates whole‐body heat loss, probably to mitigate further fluid losses and thereby support blood pressure regulation. Recently, however, we demonstrated that the hypohydration‐mediated reduction in net whole‐body heat exchange (evaporative heat loss – dry heat gain) was blunted in middle‐aged compared to younger men during moderate… Continue reading #Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress
Infection Fatality Ratios for #COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence Study
Background: Because many cases of coronavirus disease 2019 (COVID-19) are asymptomatic, generalizable data on the true number of persons infected are lacking. Mortality rates therefore are calculated from confirmed cases, which overestimates the infection fatality ratio (IFR). To calculate a true IFR, population prevalence data are needed from large geographic areas where reliable death data… Continue reading Infection Fatality Ratios for #COVID-19 Among Noninstitutionalized Persons 12 and Older: Results of a Random-Sample Prevalence Study
The temporal association between incident late‐life #depression and incident #dementia
There is an established association between depression and subsequent dementia. The present study examined temporal associations between incident late‐life depression and subsequent dementia, also considering age and sex.. ..Incident depression was associated with a higher risk of subsequent dementia (incidence rate ratios (IRR) adjusted for age and sex: IRR = 1.58, 95% CI = 1.51‐1.64).… Continue reading The temporal association between incident late‐life #depression and incident #dementia
Association Between Arterial #Stiffness, #Frailty and Fall-Related Injuries in Older Adults
..A cross-sectional study of a random sample of older adults aged 60 years and older was conducted. Main study parameters: arterial stiffness was measured by the determining the cardio-ankle vascular index (CAVI); Frailty status was defined using a 7-item frailty screening scale, developed in Russia. This questionnaire included question about falls and fall-related injuries. Orthostatic… Continue reading Association Between Arterial #Stiffness, #Frailty and Fall-Related Injuries in Older Adults
Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older
Data are limited regarding statin therapy for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in adults 75 years and older.. ..Of 326 981 eligible veterans (mean [SD] age, 81.1 [4.1] years; 97% men; 91% white), 57 178 (17.5%) newly initiated statins during the study period. During a mean follow-up of 6.8 (SD, 3.9) years, a total 206 902… Continue reading Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older
Predictors of a long length of stay in the emergency department for older people
..For older people, a long stay in the emergency department (ED) may reflect the complexity of their presentation, or deficiencies in systems that manage these complexities. ..Of 16 791 ED presentations made by older people, 4192 experienced a LLoS; 55% were admitted. Increasing age was associated with an increasing ED LoS. Factors most predictive of LLoS… Continue reading Predictors of a long length of stay in the emergency department for older people
Estimates of the severity of #coronavirus disease 2019: a model-based analysis
Using data on 24 deaths that occurred in mainland China and 165 recoveries outside of China, we estimated the mean duration from onset of symptoms to death to be 17·8 days (95% credible interval [CrI] 16·9–19·2) and to hospital discharge to be 24·7 days (22·9–28·1). In all laboratory confirmed and clinically diagnosed cases from mainland… Continue reading Estimates of the severity of #coronavirus disease 2019: a model-based analysis
BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study
Yongey Mingyur Rinpoche (YMR) is a Tibetan Buddhist monk, and renowned meditation practitioner and teacher who has spent an extraordinary number of hours of his life meditating. The brain-aging profile of this expert meditator in comparison to a control population was examined using a machine learning framework, which estimates “brain-age” from brain imaging. YMR’s brain-aging… Continue reading BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study
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