Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM… Continue reading Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory
Category: Gerontology
Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with systolic and diastolic blood pressure, and the risk of hypertension in a prospective 3-year longitudinal study in older adults… Continue reading Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
#Circadian disturbances and #frailty risk in #older adults
Frailty is characterized by diminished resilience to stressor events. It is associated with adverse future health outcomes and impedes healthy aging. The circadian system orchestrates ~24-h rhythms in bodily functions in synchrony with the day-night cycle, and disturbed circadian regulation plays an important role in many age-related health consequences. We investigated prospective associations of circadian… Continue reading #Circadian disturbances and #frailty risk in #older adults
Association Between #Triglycerides and Risk of #Dementia in Community-Dwelling #Older Adults: A Prospective Cohort Study
Background and Objectives: It has been suggested that higher triglyceride levels were associated with a lower risk of Alzheimer's disease. This study aimed to examine the association of triglycerides with dementia and cognition change in community-dwelling older adults.Methods: This prospective longitudinal study used data from the ASPREE randomized trial of adults aged ≥65 years without dementia or… Continue reading Association Between #Triglycerides and Risk of #Dementia in Community-Dwelling #Older Adults: A Prospective Cohort Study
Blood biomarker profiles and exceptional #longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort
Comparing biomarker profiles measured at similar ages, but earlier in life, among exceptionally long-lived individuals and their shorter-lived peers can improve our understanding of aging processes. This study aimed to (i) describe and compare biomarker profiles at similar ages between 64 and 99 among individuals eventually becoming centenarians and their shorter-lived peers, (ii) investigate the association… Continue reading Blood biomarker profiles and exceptional #longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort
Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative
BackgroundAssociations of weight changes and intentionality of weight loss with longevity are not well described.MethodsUsing longitudinal data from the Women’s Health Initiative (N = 54 437; 61–81 years), we examined associations of weight changes and intentionality of weight loss with survival to ages 90, 95, and 100. Weight was measured at baseline, year 3, and year 10,… Continue reading Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative
Effects of adult #education on #cognitive function and risk of #dementia in older adults: a longitudinal analysis
Introduction: Mid/late-life cognitive activities are associated with a lower rate of subsequent cognitive decline and lower subsequent dementia risk over time.Methods: In this study, we investigated the association between adult education class participation and subsequent cognitive decline and dementia risk over time after adjusting for baseline cognitive function and genetic risk of dementia, correcting for several potential… Continue reading Effects of adult #education on #cognitive function and risk of #dementia in older adults: a longitudinal analysis
Low-Dose #Aspirin and the Risk of #Stroke and Intracerebral #Bleeding in Healthy Older People Secondary Analysis of a Randomized Clinical Trial
Low-dose aspirin has been widely used for primary and secondary prevention of stroke. The balance between potential reduction of ischemic stroke events and increased intracranial bleeding has not been established in older individuals.Objective To establish the risks of ischemic stroke and intracranial bleeding among healthy older people receiving daily low-dose aspirin.Design, Setting, and Participants This secondary analysis… Continue reading Low-Dose #Aspirin and the Risk of #Stroke and Intracerebral #Bleeding in Healthy Older People Secondary Analysis of a Randomized Clinical Trial
#Constipation Associated with #Cognitive #Aging and Decline
Key Takeaways:Chronic constipation — one bowel movement every three days or more — could signal worsening cognition.People who were chronically constipated had worse cognition equal to three years of aging, according to the study, which is the first to look at constipation’s potential impact on the aging brain.The new findings add to mounting research aligning… Continue reading #Constipation Associated with #Cognitive #Aging and Decline
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