There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial. Design Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010–2017 (‘ASPirin in Reducing Events in the Elderly… Continue reading Major GI #bleeding in older persons using #aspirin: incidence and risk factors in the ASPREE randomised controlled trial
Category: Gastroenterology
#Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
Patients with type 2 diabetes (T2D) are at increased risk of both cardiovascular disease (CVD) and advanced liver fibrosis related to non-alcoholic fatty liver disease (NAFLD). Statin use is known to reduce the incidence of CVD while evidence on an effect on NAFLD severity is limited. Methods This is a cross-sectional study performed with data… Continue reading #Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
1. We recommend CRC screening in average-risk individuals between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Strong recommendation; moderate-quality evidence 2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Conditional… Continue reading ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
As an active interface between the host and their diet, the gut microbiota influences host metabolic adaptation; however, the contributions of fungi have been overlooked. Here, we investigate whether variations in gut mycobiome abundance and composition correlate with key features of host metabolism. We obtained animals from four commercial sources in parallel to test if… Continue reading The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation
Adherent-invasive E. coli (AIEC) are enriched in the intestinal microbiota of patients with Crohn’s disease (CD) and promote intestinal inflammation. Yet, how AIEC metabolism of nutrients impacts intestinal homeostasis is poorly defined. Here, we show that AIEC encoding the large subunit of propanediol dehydratase (PduC), which facilitates the utilization of fucose fermentation product 1,2-propanediol, are… Continue reading Adherent-invasive E. coli metabolism of propanediol in #Crohn’s disease regulates phagocytes to drive intestinal #inflammation
Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a… Continue reading Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition
Emerging evidence suggests that intratumoral interferon (IFN) signaling can trigger targetable vulnerabilities. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its extensively reprogrammed metabolic network, in which nicotinamide adenine dinucleotide (NAD) and its reduced form, NADH, are critical cofactors. Here, we show that IFN signaling, present in a subset of PDAC tumors, substantially lowers NAD(H)… Continue reading NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition
Effects of two personalized #dietary strategies during a 2‐year intervention in subjects with nonalcoholic #fatty #liver disease: a randomized trial
Background and objectives Nonalcoholic fatty liver disease (NAFLD) management is focused on lifestyle modifications, but long‐term maintenance is a challenge for many individuals. This study aimed to evaluate the long‐term effects of two personalized energy‐restricted dietary strategies on weight loss, metabolic and hepatic outcomes in overweight/obese subjects with NAFLD. Methods Ninety‐eight subjects from the Fatty… Continue reading Effects of two personalized #dietary strategies during a 2‐year intervention in subjects with nonalcoholic #fatty #liver disease: a randomized trial
#Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in #Liver Tumors in Mice
Immune checkpoint inhibitors have shed light on the importance of antitumor immunity as a therapeutic strategy for hepatocellular carcinoma (HCC). The altered glucose metabolism known as the Warburg effect recently has gained attention as a cancer immune-resistance mechanism. Considering glycolysis inhibitors as therapeutic agents, their specific delivery to cancer cells is critical not to induce… Continue reading #Nanoparticle-Mediated Delivery of 2-Deoxy-D-Glucose Induces Antitumor Immunity and Cytotoxicity in #Liver Tumors in Mice
2 Medical News 