Effect of Extended-Release #Naltrexone on #Alcohol Consumption: A Systematic Review and Meta-analysis

Aims1) Estimate the effect of extended-release naltrexone compared with placebo on alcohol consumption in patients with alcohol use disorder (AUD). 2) Conduct pre-planned subgroup analyses to test whether being abstinent when initiating treatment (lead-in abstinence) or the duration of treatment improves treatment efficacy. DesignSystematic review and random effects meta-analysis of blinded randomized placebo-controlled trials reporting …

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Frequent #drinking is a more important risk factor for new-onset atrial #fibrillation than binge drinking: a nationwide population-based study

Compared with patients who drink twice per week (reference group), patients who drink once per week showed the lowest risk [hazard ratio (HR) 0.933, 95% confidence interval (CI) 0.916–0.950] and those who drink everyday had the highest risk for new-onset AF (HR 1.412, 95% CI 1.373–1.453), respectively. However, the amount of alcohol intake per drinking …

Continue reading Frequent #drinking is a more important risk factor for new-onset atrial #fibrillation than binge drinking: a nationwide population-based study