The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation. Design We investigated the relation between 173… Continue reading Long-term #dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut #microbiome
Category: Gastroenterology
Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at… Continue reading Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites
Probiotic milk-fermented microorganism mixtures (e.g., yogurt, kefir) are perceived as contributing to human health, and possibly capable of protecting against bacterial infections. Co-existence of probiotic microorganisms are likely maintained via complex biomolecular mechanisms, secreted metabolites mediating cell-cell communication, and other yet-unknown biochemical pathways. In particular, deciphering molecular mechanisms by which probiotic microorganisms inhibit proliferation of… Continue reading Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites
#Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis
Gastric cancer (GC) is the fifth diagnosed cancer worldwide and the third leading cause of death for cancer. Recent reports suggest that metabolic syndrome (MetS) has a role in etiology, progression or prognosis on GC. The aim of this study is to systematically review the evidence on the association between MetS and GC risk and… Continue reading #Metabolic syndrome and #gastric cancer risk: a systematic review and meta-analysis
Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for #Helicobacter pylori Infection: a Network Meta-Analysis.
A number of double, triple and quadruple therapies have been proposed as first line H. pylori infection empiric treatments. However, knowledge of their worldwide and regional comparative efficacy is lacking. We examined the comparative effectiveness of all empirically used first line regimens tested against standard triple treatment, using a network meta-analysis (NWM) of published RCTs.… Continue reading Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for #Helicobacter pylori Infection: a Network Meta-Analysis.
High-#Fiber, Whole-Food Dietary Intervention Alters the Human Gut #Microbiome but Not Fecal Short-Chain Fatty Acids
Dietary shifts can have a direct impact on the gut microbiome by preferentially selecting for microbes capable of utilizing the various dietary nutrients. The intake of dietary fiber has decreased precipitously in the last century, while consumption of processed foods has increased. Fiber, or microbiota-accessible carbohydrates (MACs), persist in the digestive tract and can be… Continue reading High-#Fiber, Whole-Food Dietary Intervention Alters the Human Gut #Microbiome but Not Fecal Short-Chain Fatty Acids
Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality
We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association… Continue reading Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality
Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe… Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease
Alcohol-associated liver disease represents a spectrum of histopathological changes from steatosis to advanced fibrosis and cirrhosis. The major goals of this retrospective study were to characterize the histologic features in patients with excessive alcohol use who presented with an abnormal hepatic panel and/or abnormal radiographic imaging and did not meet the clinical diagnosis of alcoholic… Continue reading Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease
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