To characterize the natural course of diabetic retinopathy (DR) in contemporary clinical practice. Patients and Methods: This was a retrospective analysis of US claims data collected between January 1, 2006, and April 30, 2017. Patients aged ≥ 18 years with continuous medical and prescription insurance coverage for 18 months before DR diagnosis (index date) and… Continue reading Five-Year Patterns of #Diabetic #Retinopathy Progression in US Clinical Practice
Category: Endocrinology
Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials involving patients with chronic kidney disease (CKD) and type 2 diabetes. However, its long-term effects on kidney and cardiovascular outcomes are unknown. ..During a median follow-up of 2.6 years, a primary outcome event occurred in 504 of 2833 patients (17.8%) in the finerenone… Continue reading Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
#Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes
In EMPA‐REG MET, in patients with type 2 diabetes mellitus (T2DM) on stable background metformin (≥1500 mg/day), empagliflozin versus placebo significantly improved glycated haemoglobin (HbA1c), body weight (BW), and systolic blood pressure (SBP) over 24 and ≤76 weeks. This analysis investigated empagliflozin treatment effects by baseline cardio‐metabolic factors.. ..In total, 637 patients (56.7% males; mean [SD]… Continue reading #Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes
#BMI and All‐Cause #Mortality in a Population‐Based Cohort in Rural South Africa
..The cohort consisted of 9,728 individuals. In adjusted models, those with BMI of 25.0 to 29.9 kg/m2 or 30.0 to 34.9 kg/m2 had a lower hazard of death (adjusted hazard ratio: 0.80; 95% CI: 0.69‐0.92 and adjusted hazard ratio: 0.75; 95% CI: 0.60‐0.93, respectively) compared with those with BMI of 18.5 to 24.9 kg/m2. Conclusions… Continue reading #BMI and All‐Cause #Mortality in a Population‐Based Cohort in Rural South Africa
Additive effects of green #tea and #coffee on all-cause mortality in patients with type 2 #diabetes mellitus: the Fukuoka Diabetes Registry
The impact of consuming green tea or coffee on mortality in patients with diabetes is controversial. We prospectively investigated the impact of each beverage and their combination on mortality among Japanese patients with type 2 diabetes.. ..During the follow-up period, 309 participants died. The consumption of green tea, coffee, and a combination of the beverages… Continue reading Additive effects of green #tea and #coffee on all-cause mortality in patients with type 2 #diabetes mellitus: the Fukuoka Diabetes Registry
644 – Development of noninvasive #diabetes monitoring method using #tear samples
To prevent diabetic complications, strict glucose control and frequent monitoring of blood glucose levels are necessary. However, all currently available methods for blood glucose monitoring, including the finger prick method, are invasive. Therefore, noninvasive blood glucose monitoring approaches have been investigated, but until date, none has been found to be a suitable substitute for direct… Continue reading 644 – Development of noninvasive #diabetes monitoring method using #tear samples
#Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study
Obesity shortens life expectancy. Bariatric surgery is known to reduce the long-term relative risk of death, but its effect on life expectancy is unclear.. ..In total, 2007 and 2040 patients were included in the surgery group and the control group, respectively, and 1135 participants were included in the reference cohort. At the time of the… Continue reading #Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study
#Dapagliflozin in Patients with Chronic #Kidney Disease
Patients with chronic kidney disease have a high risk of adverse kidney and cardiovascular outcomes. The effect of dapagliflozin in patients with chronic kidney disease, with or without type 2 diabetes, is not known.. ..The independent data monitoring committee recommended stopping the trial because of efficacy. Over a median of 2.4 years, a primary outcome… Continue reading #Dapagliflozin in Patients with Chronic #Kidney Disease
Trends in #Adiposity and #Food Insecurity Among US Adults
..Food insecurity is a core indicator of nutritional status and “exists whenever the availability of nutritionally adequate and safe foods or the ability to acquire acceptable foods in socially acceptable ways is limited or uncertain.” ..Main Outcomes and Measures The primary outcome was food insecurity. Data on BMI (calculated as weight in kilograms divided by… Continue reading Trends in #Adiposity and #Food Insecurity Among US Adults
