It is thought that a reduction in the frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analogue designed for once-weekly administration that is in development for the treatment of diabetes We conducted a 26-week, randomized, double-blind, double-dummy, phase 2 trial… Continue reading Once-Weekly #Insulin for Type 2 #Diabetes without Previous Insulin Treatment
Category: Endocrinology
#Loneliness and type 2 #diabetes incidence: findings from the English Longitudinal Study of Ageing
Loneliness is associated with all-cause mortality and coronary heart disease. However, the prospective relationship between loneliness and type 2 diabetes onset is unclear.. ..A total of 264 (6.42%) participants developed type 2 diabetes over the follow-up period. Loneliness was a significant predictor of incident type 2 diabetes (HR 1.46; 95% CI 1.15, 1.84; p = 0.002) independent… Continue reading #Loneliness and type 2 #diabetes incidence: findings from the English Longitudinal Study of Ageing
Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study
Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.. ..During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were… Continue reading Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study
An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study
..We found evidence of causal associations between 34 exposures (19 risk factors and 15 protective factors) and type 2 diabetes. Insomnia was identified as a novel risk factor (OR 1.17 [95% CI 1.11, 1.23]). The other 18 risk factors were depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine and leucine,… Continue reading An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study
#Obesity Has a Stronger Relationship with Colorectal #Cancer in Postmenopausal Women Than Premenopausal Women
Background: To examine the relationship between obesity measured by waist circumference (WC) and body mass index (BMI) and the incidence of colorectal cancer (CRC) in premenopausal and postmenopausal women. Methods: A total of 1,418,180 premenopausal and 4,854,187 postmenopausal women without cancer at baseline and aged over 40 were identified using the Korean National Health Insurance… Continue reading #Obesity Has a Stronger Relationship with Colorectal #Cancer in Postmenopausal Women Than Premenopausal Women
Associations of #Sleep Disordered #Breathing and Insomnia with Incident #Hypertension and #Diabetes: The Hispanic Community Health Study/Study of Latinos
Rationale: Sleep disorders are associated with hypertension and diabetes, primary risk factors for cardiovascular diseases and mortality. It is important to understand these associations in Hispanics/Latinos, in whom cardiovascular death is the leading cause of mortality. Objectives: To investigate the prospective associations of sleep disordered breathing (SDB) and insomnia with incident hypertension and diabetes among… Continue reading Associations of #Sleep Disordered #Breathing and Insomnia with Incident #Hypertension and #Diabetes: The Hispanic Community Health Study/Study of Latinos
Risk of #amputation with #canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study
..Results Across the three databases, 310 840 propensity score matched adults who started canagliflozin or a GLP-1 agonist were identified. The hazard ratio and rate difference per 1000 person years for amputation in adults receiving canagliflozin compared with a GLP-1 agonist for each group was: group 1, hazard ratio 1.09 (95% confidence interval 0.83 to 1.43),… Continue reading Risk of #amputation with #canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study
Effects of #Diet versus Gastric #Bypass on Metabolic Function in Diabetes
Some studies have suggested that in people with type 2 diabetes, Roux-en-Y gastric bypass has therapeutic effects on metabolic function that are independent of weight loss.. ..Weight loss was associated with increases in mean suppression of glucose production from baseline, by 7.04 μmol per kilogram of fat-free mass per minute (95% confidence interval [CI], 4.74… Continue reading Effects of #Diet versus Gastric #Bypass on Metabolic Function in Diabetes
#Migraine, obesity and body #fat distribution – a population-based study
Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between obesity and headache in a large, population-based study where we could take into account body fat distribution, migraine subtypes and tension-type headache.. ..Both total body… Continue reading #Migraine, obesity and body #fat distribution – a population-based study
