Objective Despite the strong association between gout and pre-diabetes, the role of metformin in gout among individuals with pre-diabetes remains uncertain. We compared the incidence rates of gout in adults with pre-diabetes starting metformin with those not using antidiabetic treatments.Methods We conducted a new-user, propensity score-matched cohort study using electronic health records from an academic health system… Continue reading #Gout risk in adults with pre-#diabetes initiating metformin
Category: Endocrinology
Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1
Background/ObjectiveInsulin resistance is more prominent in men than women. If this involves adipose tissue is unknown and was presently examined.Subjects/MethodsAdipoIR (in vivo adipose insulin resistance index) was measured in 2344 women and 787 men. In 259 of the women and 54 of the men, insulin induced inhibition of lipolysis (acylglycerol breakdown) and stimulation of lipogenesis… Continue reading Sex differences in #adipose #insulin resistance are linked to #obesity, lipolysis and insulin receptor substrate 1
Use of ancient #grains for the management of #diabetes mellitus: A systematic review and meta-analysis
Highlights•Oats, brown rice, and millet improve health outcomes in diabetes mellitus type 2.•The most prevalent grains tested in trials included oats, brown rice, and buckwheat.•The most outcomes studied in diabetes were related to cardiovascular risk factors.AimsA systematic review and meta-analysis of published randomized controlled trials was conducted to collate evidence from studies implementing ancient grains… Continue reading Use of ancient #grains for the management of #diabetes mellitus: A systematic review and meta-analysis
Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Experimental studies have suggested potential detrimental effects of emulsifiers on gut microbiota, inflammation, and metabolic perturbations. We aimed to investigate the associations between exposures to food additive emulsifiers and the risk of type 2 diabetes in a large prospective cohort of French adults.MethodsWe analysed data from 104 139 adults enrolled in the French NutriNet-Santé prospective cohort… Continue reading Food #additive emulsifiers and the risk of type 2 #diabetes: analysis of data from the NutriNet-Santé prospective cohort study
Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and diabetes worldwide. Here we investigated FG values using continuous glucose monitoring (CGM) devices in nondiabetic adults aged 40–70 years. FG was measured during 59,565 morning windows of 8,315 individuals (7.16 ± 3.17 days per participant). Mean FG was 96.2 ± 12.87 mg dl−1, rising by 0.234 mg dl−1 per year with… Continue reading Continuous #glucose monitoring and intrapersonal variability in fasting #glucose
In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
Globaplastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals… Continue reading In Vivo Tissue Distribution of #Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice
#Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.Objective To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.Design, Setting, and Participants This large-scale,… Continue reading #Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimer’s-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimer’s risk.The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.Key Facts:Molecular… Continue reading Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
Background and aims Obesity and overweight have become significant health concerns worldwide, leading to an increased interest in finding natural remedies for weight reduction. One such remedy that has gained popularity is apple cider vinegar (ACV).Objective To investigate the effects of ACV consumption on weight, blood glucose, triglyceride and cholesterol levels in a sample of the Lebanese… Continue reading Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
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