This study investigates the impact of habitual late calorie intake on glucose metabolism in adults with overweight or obesity and diet or metformin-controlled prediabetes or type 2 diabetes independently of body weight, fat mass, energy intake or diet composition. Participants (n = 26) were classified as Later Eaters (LE) if ≥45% daily calories were consumed after 5 pm… Continue reading Late #eating is associated with poor #glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 #diabetes
Category: Endocrinology
Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
#Empagliflozin and the Risk of #Retinopathy in Patients With Type 2 Diabetes
Question Is there an association between empagliflozin and the risk of nonproliferative diabetic retinopathy (NPDR) and diabetic retinopathy (DR) progression in patients with type 2 diabetes (T2D)?Findings In this cohort study, there was no association between empagliflozin and incident NPDR in patients with T2D who had no DR history; however, empagliflozin was associated with a… Continue reading #Empagliflozin and the Risk of #Retinopathy in Patients With Type 2 Diabetes
#Chocolate intake and risk of type 2 #diabetes: prospective cohort studies
Objective To prospectively investigate the associations between dark, milk, and total chocolate consumption and risk of type 2 diabetes (T2D) in three US cohorts.Design Prospective cohort studies.Setting Nurses’ Health Study (NHS; 1986-2018), Nurses’ Health Study II (NHSII; 1991-2021), and Health Professionals Follow-Up Study (HPFS; 1986-2020).Participants At study baseline for total chocolate analyses (1986 for NHS… Continue reading #Chocolate intake and risk of type 2 #diabetes: prospective cohort studies
Day-to-day associations between #testosterone, #sexual desire and #courtship efforts in young men
Testosterone plays important roles in reproductive behaviour in many species. Despite a common belief that testosterone regulates fluctuations in human sexual desire, there is little direct evidence that relates within-person changes in natural testosterone production to within-person changes in sexual desire. Here, we measured daily salivary testosterone concentrations from 41 adult men for one month,… Continue reading Day-to-day associations between #testosterone, #sexual desire and #courtship efforts in young men
#LEVOTHYROXINE USE AND #BONE LOSS IN #EUTHYROID #OLDER ADULTS: A LONGITUDINAL ANALYSIS FROM BALTIMORE LONGITUDINAL STUDY OF AGING | S3B-SPMS-1
Purpose: Levothyroxine (LT4) is the second most commonly prescribed medication in older adults. Frank hyperthyroidism accelerates bone turnover and even subclinical hyperthyroid has been associated with increased fracture risk. Data indicates that a significant proportion of thyroid hormone prescriptions may be given to older adults without hypothyroidism raising concerns about subsequent relative excess of thyroid… Continue reading #LEVOTHYROXINE USE AND #BONE LOSS IN #EUTHYROID #OLDER ADULTS: A LONGITUDINAL ANALYSIS FROM BALTIMORE LONGITUDINAL STUDY OF AGING | S3B-SPMS-1
Once-Weekly #Semaglutide in Persons with #Obesity and #Knee Osteoarthritis
BackgroundWeight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis among persons with obesity has not been well studied.MethodsWe conducted a 68-week, double-blind, randomized, placebo-controlled trial at 61 sites in 11 countries. Participants with obesity (a body-mass index… Continue reading Once-Weekly #Semaglutide in Persons with #Obesity and #Knee Osteoarthritis
Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
INTRODUCTIONEmerging preclinical evidence suggests that semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA) for type 2 diabetes mellitus (T2DM) and obesity, protects against neurodegeneration and neuroinflammation. However, real-world evidence for its ability to protect against Alzheimer's disease (AD) is lacking.METHODSWe conducted emulation target trials based on a nationwide database of electronic health records (EHRs) of 116… Continue reading Associations of #semaglutide with first-time diagnosis of #Alzheimer’s disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US
A single bout of physical #exercise improves 1-hour post-load plasma #glucose in healthy young adults
PurposePhysical exercise is a key component in the treatment of type 2 diabetes and plays an important role in maintaining a healthy glucose metabolism even in healthy subjects. To date, no studies have investigated the effect of a single bout of aerobic physical exercise on glucose metabolism in young, moderately active, healthy adults.MethodsWe performed an… Continue reading A single bout of physical #exercise improves 1-hour post-load plasma #glucose in healthy young adults
