Objectives To evaluate the individual and combined associations of five modifiable risk factors with risk of type 2 diabetes among women with a history of gestational diabetes mellitus and examine whether these associations differ by obesity and genetic predisposition to type 2 diabetesSetting Nurses’ Health Study II, US.Participants 4275 women with a history of gestational diabetes mellitus, with… Continue reading Modifiable risk factors and long term risk of type 2 diabetes among individuals with a history of gestational diabetes mellitus: prospective cohort study
Category: Diet
Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China
Dear Editor,Worldwide, around 55 million people had prevalent dementia in 2019, which is expected to triple by 2050, especially in low- and middle-income countries. Lacking timely diagnosis and limited effective treatment for dementia make identifying risk factors crucial for its early prevention, among which dietary factors have received increasing attention.Recently, accumulating evidence from population-based studies… Continue reading Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies
Evidence suggests that spironolactone, a nonselective mineralocorticoid receptor (MR) antagonist, modulates alcohol seeking and consumption. Therefore, spironolactone may represent a novel pharmacotherapy for alcohol use disorder (AUD). In this study, we tested the effects of spironolactone in a mouse model of alcohol drinking (drinking-in-the-dark) and in a rat model of alcohol dependence (vapor exposure). We… Continue reading Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies
Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
Highlights•Innate immune system receptors/interferon/Stat1 axis triggers inflammaging•Both lifetime and short-time dietary restriction (DR) treatments ameliorate inflammaging•Transcriptome alteration caused by aging, lifetime, or short-term DR are tissue specific•Aging induces a general open chromatin rearrangement, which is not rescued by DRSummaryAging is characterized by a chronic low-grade inflammation known as inflammaging in multiple tissues, representing a risk… Continue reading Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
Association of nut consumption with CVD risk factors in young to middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Highlights•Walnut and nut consumers had higher HEI2015 diet quality scores than those who do not consume nuts.•Walnut consumers had a better CVD risk profile than other nut and no nut consumers.•Our study findings support the health claim to include walnuts as part of a healthy diet.AbstractBackground and aimsFew studies have examined long-term associations of walnut,… Continue reading Association of nut consumption with CVD risk factors in young to middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort
Objectives To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, and sucralose), and risk of cardiovascular diseases (overall, coronary heart disease, and cerebrovascular disease).Design Population based prospective cohort study (2009-21).Setting France, primary prevention research.Participants 103 388 participants of the web based NutriNet-Santé… Continue reading Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort
Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
Tea is frequently consumed worldwide, but the association of tea drinking with mortality risk remains inconclusive in populations where black tea is the main type consumed.Objective:To evaluate the associations of tea consumption with all-cause and cause-specific mortality and potential effect modification by genetic variation in caffeine metabolism.Design:Prospective cohort study.Setting:The UK Biobank.Participants:498 043 men and women aged… Continue reading Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
Breakfast and psychosocial behavioural problems in young population: The role of status, place, and habits
The aim of this study was to examine whether breakfast status, place and habits are associated with psychosocial behavioural problems in a nationally representative sample of young people aged 4–14 years residing in Spain. This study analysed secondary data from the Spanish National Health Survey (2017), including 3,772 Spanish children and adolescents. Breakfast status, place,… Continue reading Breakfast and psychosocial behavioural problems in young population: The role of status, place, and habits
Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
AbstractBackgroundLow vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.MethodsMR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from… Continue reading Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
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