Highlights•Innate immune system receptors/interferon/Stat1 axis triggers inflammaging•Both lifetime and short-time dietary restriction (DR) treatments ameliorate inflammaging•Transcriptome alteration caused by aging, lifetime, or short-term DR are tissue specific•Aging induces a general open chromatin rearrangement, which is not rescued by DRSummaryAging is characterized by a chronic low-grade inflammation known as inflammaging in multiple tissues, representing a risk… Continue reading Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
Category: Diet
Association of nut consumption with CVD risk factors in young to middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Highlights•Walnut and nut consumers had higher HEI2015 diet quality scores than those who do not consume nuts.•Walnut consumers had a better CVD risk profile than other nut and no nut consumers.•Our study findings support the health claim to include walnuts as part of a healthy diet.AbstractBackground and aimsFew studies have examined long-term associations of walnut,… Continue reading Association of nut consumption with CVD risk factors in young to middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort
Objectives To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, and sucralose), and risk of cardiovascular diseases (overall, coronary heart disease, and cerebrovascular disease).Design Population based prospective cohort study (2009-21).Setting France, primary prevention research.Participants 103 388 participants of the web based NutriNet-Santé… Continue reading Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort
Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
Tea is frequently consumed worldwide, but the association of tea drinking with mortality risk remains inconclusive in populations where black tea is the main type consumed.Objective:To evaluate the associations of tea consumption with all-cause and cause-specific mortality and potential effect modification by genetic variation in caffeine metabolism.Design:Prospective cohort study.Setting:The UK Biobank.Participants:498 043 men and women aged… Continue reading Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank
Breakfast and psychosocial behavioural problems in young population: The role of status, place, and habits
The aim of this study was to examine whether breakfast status, place and habits are associated with psychosocial behavioural problems in a nationally representative sample of young people aged 4–14 years residing in Spain. This study analysed secondary data from the Spanish National Health Survey (2017), including 3,772 Spanish children and adolescents. Breakfast status, place,… Continue reading Breakfast and psychosocial behavioural problems in young population: The role of status, place, and habits
Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
AbstractBackgroundLow vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.MethodsMR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from… Continue reading Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis
Objectives The Salt Substitute and Stroke Study (SSaSS) recently reported blood pressure-mediated benefits of a potassium-enriched salt substitute on cardiovascular outcomes and death. This study assessed the effects of salt substitutes on a breadth of outcomes to quantify the consistency of the findings and understand the likely generalisability of the SSaSS results.Methods We searched PubMed,… Continue reading Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis
Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections—Sepsis and COVID-19
Vitamin D deficiency is a global public health problem, a pandemic that commonly affects the elderly and those with comorbidities such as obesity, diabetes, hypertension, respiratory disorders, recurrent infections, immune deficiency, and malignancies, as well as ethnic minorities living in temperate countries. The same groups were worst affected by COVID-19. Since vitamin D deficiency weakens… Continue reading Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections—Sepsis and COVID-19
High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression
ObjectiveVitamins B6 and B12 are involved in metabolic processes that decrease neural excitation and increase inhibition. This double-blind study investigated the effects of supplementation for 1 month with a high-dose of B6 or B12, compared to placebo, on a range of behavioural outcome measures connected to the balance between neural inhibition and excitation.Methods478 young adults… Continue reading High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression
