We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.MethodsWe enrolled SLE patients without traditional cardiovascular risks factors. Caffeine intake was evaluated with a 7-day food… Continue reading #Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
Category: Diet
Modeling sex-specific whole-body metabolic responses to #feeding and #fasting
Highlights•Sex-specific model reveals mechanisms of sexual dimorphism in glucose production.•Female model shows higher gluconeogenesis from glycerol during fasting.•TG-FFA cycle facilitates liver fat removal in females through TG secretion. AbstractMen generally favor carbohydrate metabolism, while women lean towards lipid metabolism, resulting in significant sex-based differences in energy oxidation across various metabolic states such as fasting and… Continue reading Modeling sex-specific whole-body metabolic responses to #feeding and #fasting
#Dietary restriction impacts health and #lifespan of genetically diverse mice
Caloric restriction extends healthy lifespan in multiple species1. Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in humans, but its effectiveness remains largely unexplored2,3,4,5,6,7,8. Identifying the most efficacious forms of dietary restriction is key for developing interventions to improve human health and longevity9. Here we performed an extensive assessment of graded… Continue reading #Dietary restriction impacts health and #lifespan of genetically diverse mice
#Ultra-processed foods and health: are we correctly interpreting the available evidence?
Several studies have linked adverse health effects to the consumption of ultra-processed foods (UPF) according to the NOVA classification. However, whether the consumption of UPF is the actual causal factor for such health outcomes is still unknown. Indeed, different groups of UPF examined in the same epidemiologic study often show markedly different associations with the… Continue reading #Ultra-processed foods and health: are we correctly interpreting the available evidence?
Brazil #Nut (Bertholletia excelsa H.B.K.) Consumption in Energy-Restricted Intervention Decreases Proinflammatory Markers and #Intestinal Permeability of Women with Overweight/Obesity: A Controlled Trial (Brazilian Nuts Study)
BackgroundObesity is associated with low-grade inflammation and increased intestinal permeability (IP). The Brazil nut (BN) (Bertholletia excelsa H.B.K.) appears to be a promising dietary intervention to control inflammation by enhancing antioxidant defenses.ObjectivesWe aimed to assess the effect of daily BN consumption on inflammatory biomarkers and IP in the context of an energy-restricted intervention. Furthermore, we… Continue reading Brazil #Nut (Bertholletia excelsa H.B.K.) Consumption in Energy-Restricted Intervention Decreases Proinflammatory Markers and #Intestinal Permeability of Women with Overweight/Obesity: A Controlled Trial (Brazilian Nuts Study)
Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers. We performed a meta-analysis of randomized controlled trials (RCTs) published until March 2024 that reported estimates for the effects of… Continue reading Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Lifestyle habits after middle age significantly impact the maintenance of cognitive function in older adults. Nutritional intake is closely related to lifestyle habits; therefore, nutrition is a pivotal factor in the prevention of dementia in the preclinical stages. Matcha green tea powder (matcha), which contains epigallocatechin gallate, theanine, and caffeine, has beneficial effects on cognitive… Continue reading Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
#Lignan Intake and Type 2 #Diabetes Incidence Among US Men and Women
Importance Lignans are phytoestrogens abundant in Western diets and may be associated with type 2 diabetes (T2D) risk.Objective To prospectively investigate associations between lignan intake and T2D incidence.Design, Setting, and Participants Population-based cohort study of US men and women enrolled in the Nurses’ Health Study (NHS, 1984-2018), NHSII (1991-2019), and Health Professionals Follow-Up Study (HPFS, 1986-2020), as well… Continue reading #Lignan Intake and Type 2 #Diabetes Incidence Among US Men and Women
Estimated Exposure to 6 Potentially #Hepatotoxic Botanicals in US Adults
Importance Use of herbal and dietary supplements (HDSs) accounts for an increasing proportion of drug hepatotoxicity cases. Turmeric or curcumin, green tea extract, Garcinia cambogia, black cohosh, red yeast rice, and ashwagandha are the most frequently reported hepatoxic botanicals, but their prevalence and reasons for use in the general population are unknown.Objective To assess the prevalence and clinical… Continue reading Estimated Exposure to 6 Potentially #Hepatotoxic Botanicals in US Adults
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