Objectives: Insulin resistance and progressive decline in functional β-cell mass are two key factors for developing type 2 diabetes (T2D), which is largely driven by overweight and obesity, a significant obstacle for effective metabolic control in many patients with T2D. We recently found that elenolic acid (EA), a small molecule derived from olive can directly stimulate intestinal… Continue reading (OR02-02-24) Identification of a Novel Multi-target Bioactive Compound With Anti-#obesity and Anti-#diabetic Activities
Author: aledopress
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#Acupuncture and #Sleep Quality Among Patients With #Parkinson DiseaseA Randomized Clinical Trial
Importance Poor sleep quality greatly impairs quality of life and accelerates deterioration in patients with Parkinson disease (PD), but current remedies remain limited. Acupuncture, used as an adjunctive therapy with anti-Parkinson medications, has shown positive effects in patients with PD. However, high-quality clinical evidence to support the effectiveness of acupuncture for patients with PD and poor… Continue reading #Acupuncture and #Sleep Quality Among Patients With #Parkinson DiseaseA Randomized Clinical Trial
Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
Importance Patients with atrial fibrillation (AF) can have an ischemic stroke (IS) despite oral anticoagulant (OAC) treatment. Knowledge regarding the association between OAC discontinuation and the subsequent risk of recurrent IS in patients with AF is limited.Objectives To determine the risk of recurrent IS in patients with AF receiving OAC and to evaluate the association between OAC… Continue reading Recurrent Ischemic #Stroke in Patients With Atrial #Fibrillation While Receiving Oral Anticoagulants
#Urticaria and the risk of #cancer: a Danish population-based cohort study
BackgroundUrticaria has been tentatively linked to cancer, but epidemiological evidence supporting this link is sparse and conflicting. We therefore conducted a population-based cohort study using healthcare databases of the Danish population (January 1980–December 2022). We followed 87,507 people for a median of 10.1 years after first hospital contact for urticaria.ObjectivesTo examine associations of a hospital… Continue reading #Urticaria and the risk of #cancer: a Danish population-based cohort study
Proteomic predictors of individualized nutrient-specific #insulin secretion in #health and #disease
Insulin secretion to 3 model macronutrients in 140 human islet donors is defined•Deep phenotyping and multi-omics reveal personalized nutrient-specific insulin release•A subset of donors with a unique proteome exhibits large insulin responses to lipids•Nutrient responsiveness in stem cell-derived islets is dysregulatedSummaryPopulation-level variation and mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain… Continue reading Proteomic predictors of individualized nutrient-specific #insulin secretion in #health and #disease
Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
BackgroundSome cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time using published population-based cohort studies that had used consistent methods with each wave and aimed to quantify associated changes in… Continue reading Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
Genome-wide association studies of #coffee intake in UK/US participants of European ancestry uncover cohort-specific #genetic associations
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N = 130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across hundreds of biomarkers, health, and lifestyle traits, then… Continue reading Genome-wide association studies of #coffee intake in UK/US participants of European ancestry uncover cohort-specific #genetic associations
Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
BackgroundWe aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM)MethodsCross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including… Continue reading Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
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