..Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary… Continue reading Tolerability and Immunogenicity After a Late Second #Dose or a Third Dose of ChAdOx1 #nCoV-19 (AZD1222)
Author: aledopress
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Relation of Intravascular #Volume Profiles to #Heart Failure Progression and Clinical Outcomes
Heart failure (HF) commonly progresses over time and identifying differences in volume profiles may help stratify risk and guide therapy. The aim of this study was to assess the pathophysiologic and prognostic roles of volume profiles for HF progression in stable ambulatory and hospitalized patients. HF patients who had undergone quantitative intravascular volume analysis (185… Continue reading Relation of Intravascular #Volume Profiles to #Heart Failure Progression and Clinical Outcomes
Self-tunable engineered yeast #probiotics for the treatment of #inflammatory bowel disease
Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activates purinergic signaling, promoting intestinal inflammation and pathology. Based on the role of eATP in intestinal inflammation, we developed yeast-based engineered probiotics that express a human P2Y2 purinergic receptor… Continue reading Self-tunable engineered yeast #probiotics for the treatment of #inflammatory bowel disease
The temporal representation of #experience in subjective #mood
Humans refer to their mood state regularly in day-to-day as well as clinical interactions. Theoretical accounts suggest that when reporting on our mood we integrate over the history of our experiences; yet, the temporal structure of this integration remains unexamined. Here, we use a computational approach to quantitatively answer this question and show that early… Continue reading The temporal representation of #experience in subjective #mood
Review of the Emerging Evidence Demonstrating the Efficacy of #Ivermectin in the Prophylaxis and Treatment of #COVID-19
This is a provisional file, not the final typeset article Article.pdfDownload
#Gut microbes impact #stroke severity via the trimethylamine N-oxide pathway
Clinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk. However, a causal role of gut microbes in stroke has not yet been demonstrated. Herein we show that gut microbes, through dietary choline and TMAO generation, directly impact cerebral infarct size and adverse outcomes following stroke. Fecal… Continue reading #Gut microbes impact #stroke severity via the trimethylamine N-oxide pathway
Passive transfer of #fibromyalgia symptoms from patients to mice
Fibromyalgia syndrome (FMS) is characterized by widespread pain and tenderness, and patients typically experience fatigue and emotional distress. The etiology and pathophysiology of fibromyalgia are not fully explained and there are no effective drug treatments. Here we show that IgG from FMS patients produced sensory hypersensitivity by sensitizing nociceptive neurons. Mice treated with IgG from… Continue reading Passive transfer of #fibromyalgia symptoms from patients to mice
Predictive factors of #smell recovery in a clinical series of 288 #COVID-19 patients with olfactory dysfunction
To evaluate potential predictive factors of smell recovery in a clinical series of 288 patients presenting olfactory dysfunction (OD) related to the COVID19. Potential correlations are sought between epidemiological, clinical and immunological characteristics of patients and the persistence of OD at 60 days. MethodsCOVID-19 positive patients presenting olfactory dysfunction were prospectively recruited from three European… Continue reading Predictive factors of #smell recovery in a clinical series of 288 #COVID-19 patients with olfactory dysfunction
Low #muscle mass in #older adults and mortality: A systematic review and meta-analysis
Sarcopenia comprises a loss of muscle function and muscle mass. So far, the association between the later and mortality in older adults is inconsistent. A meta-analysis was performed to assess whether muscle mass measured by appendicular skeletal muscle mass index (ASMI) is associated with higher mortality in older adults. Articles of interest were searched for… Continue reading Low #muscle mass in #older adults and mortality: A systematic review and meta-analysis
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