Background High blood pressure is a leading cardiovascular disease risk factor and considered to be associated with psychological factors. However, the causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being are not clear.Aims The current study explored the genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.Methods Mendelian randomisation… Continue reading Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being
Author: aledopress
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Persistent Asthma Is Associated With Carotid Plaque in MESA
BackgroundAsthma and atherosclerotic cardiovascular disease share an underlying inflammatory pathophysiology. We hypothesized that persistent asthma is associated with carotid plaque burden, a strong predictor of atherosclerotic cardiovascular disease events.Methods and ResultsThe MESA (Multi‐Ethnic Study of Atherosclerosis) enrolled adults free of known atherosclerotic cardiovascular disease at baseline. Subtype of asthma was determined at examination 1. Persistent… Continue reading Persistent Asthma Is Associated With Carotid Plaque in MESA
Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
AbstractAsymptomatic blood donors can transmit human parvovirus B19 (B19V). We assessed the B19V prevalence amongst a large cohort of blood donations collected in Germany during 2015-2018. In total, 167,123 donations were screened for B19V DNA with 22 cases of viraemia identified (0.013% positive). Infections peaked at a four-year interval and the highest number of cases… Continue reading Prevalence of parvovirus B19 viraemia among German blood donations and the relationship to ABO and Rhesus blood group antigens
Community-level age bias and older adult mortality
As the older adult population increases, understanding the health effects of bias against older adults is increasingly important. Whether structural forms of age bias predict worse health has received limited attention.ObjectiveWe hypothesized that communities with greater age bias would have higher mortality among residents aged 65 and older. We expected the association to be unique… Continue reading Community-level age bias and older adult mortality
Low-Energy Dense Potato- and Bean-Based Diets Reduce Body Weight and Insulin Resistance: A Randomized, Feeding, Equivalence Trial
AbstractWe evaluated the effect of diets low in energy density (1 kcal/g) and high in either potatoes (Potato) or pulses (Bean) on blood glucose control in participants with insulin resistance. We hypothesized that the Potato and Bean diets would have equivalent effects. This was an 8-week randomized, parallel design, controlled feeding study comparing Potato and… Continue reading Low-Energy Dense Potato- and Bean-Based Diets Reduce Body Weight and Insulin Resistance: A Randomized, Feeding, Equivalence Trial
Dysregulated amino acid sensing drives colorectal cancer growth and metabolic reprogramming leading to chemoresistance
Background and AimsCRC is a devastating disease highly modulated by dietary nutrients. mTORC1 contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism of mTORC1 activation. However, compensatory pathways exist to sustain mTORC1 activity following therapies that target oncogenic growth factor signaling. Amino acids potently activate mTORC1 via amino acid… Continue reading Dysregulated amino acid sensing drives colorectal cancer growth and metabolic reprogramming leading to chemoresistance
Migration of Microplastics and Phthalates from Face Masks to Water
Since the outbreak of COVID-19, face masks have been introduced in the complex strategy of infection prevention and control. Face masks consist of plastic polymers and additives such as phthalates. The aim of this study was to evaluate the migration of microplastics (MP) and phthalates from face masks to water. Four types of masks including… Continue reading Migration of Microplastics and Phthalates from Face Masks to Water
Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation
Uterine leiomyomas (or fibroids) represent the most common tumor affecting up to 80% of reproductive-age women. Epidemiological studies consistently indicate a positive association between exposure to endocrine-disrupting phthalates and leiomyoma risk; however, the underlying mechanisms remain unclear. Here, we demonstrate that the ubiquitous environmental pollutant mono-(2-ethyl-5-hydroxyhexyl) phthalate [MEHHP, the major metabolite of di-(2-ethylhexyl) phthalate] promotes… Continue reading Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation
An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind this relationship remains mostly unknown. Here we report that exercise induces the metabolic reprogramming of internal organs that increases nutrient demand and protects against metastatic colonization by limiting nutrient availability to the tumor, generating an exercise-induced metabolic shield. Proteomic and ex vivo metabolic capacity analyses of… Continue reading An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
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