Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Clinical outcomes of #orthopaedic surgery patients with inferior vena #cava filter prophylaxis
AbstractPurpose: Orthopaedic surgery patients are at an elevated risk of venous thromboembolic events thus necessitating effective prophylaxis strategies.Methods: This IRB-approved, single-center retrospective study evaluated patients who underwent orthopaedic surgery and were protected with Inferior Vena Cava (IVC) filters from January 2007 to December 2021. Study outcomes include incidence of venous thromboembolism (VTE) in the form… Continue reading Clinical outcomes of #orthopaedic surgery patients with inferior vena #cava filter prophylaxis
Practical #guidelines on medical management of adults with moderate-to-severe #inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder that predominantly includes Crohn’s disease (CD) and ulcerative colitis (UC). IBD has emerged as a significant healthcare challenge in Saudi Arabia, with a more than fivefold increase in annual incidence over the past 2 decades. These guidelines promote high-quality, evidence-based care for adult patients with… Continue reading Practical #guidelines on medical management of adults with moderate-to-severe #inflammatory bowel disease
The Overlooked Driver of #Hypertension: Mental #Stress at the Crossroad of Cardiology and Psychiatry
AbstractPurpose of ReviewMental stress has long been overlooked in the development of hypertension. We aim to provide new insights for clinicians in managing this condition.This review aims to summarize the epidemiological characteristics, complex mechanisms, diagnostic methods, as well as both non-pharmacological and pharmacological treatment strategies for mental stress-induced hypertension.Recent FindingsMany hypertensive patients continue to experience… Continue reading The Overlooked Driver of #Hypertension: Mental #Stress at the Crossroad of Cardiology and Psychiatry
Dual target, dual benefit: real-world effects of #SGLT2 inhibitors and #GLP-1 receptor agonists on the FIB-4 score in people with type 2 #diabetes mellitus
Liver fibrosis is a serious comorbidity of type 2 diabetes mellitus (T2DM) in which non-invasive indices such as FIB-4 are used to monitor hepatic health. This study assesses the impact of GLP-1 receptor agonists (GLP-1RA), SGLT2 inhibitors (SGLT2i), and their combinations on FIB-4 scores in people with T2DM.MethodsWe conducted a retrospective analysis of 133 adults… Continue reading Dual target, dual benefit: real-world effects of #SGLT2 inhibitors and #GLP-1 receptor agonists on the FIB-4 score in people with type 2 #diabetes mellitus
Inhibition of CXCL10 and IFN-γ ameliorates #myocarditis in preclinical models of SARS-CoV-2 #mRNA vaccination
Messenger RNA (mRNA) vaccines against SARS-CoV-2 are highly effective and were instrumental in curbing the COVID-19 pandemic. However, rare cases of noninfective myocarditis, particularly in young males and typically after the second dose, have been observed. Here, we explore the mediators of this myocarditis to better understand and to enhance the safety of future mRNA… Continue reading Inhibition of CXCL10 and IFN-γ ameliorates #myocarditis in preclinical models of SARS-CoV-2 #mRNA vaccination
#Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
This study aimed to determine if sodium-glucose co-transporter-2 inhibitors (SGLT2i) use in diabetic patients leads to erythrocytosis and increases the incidence of arterial and venous thrombosis events. This is a retrospective cohort study using records from over 50 U.S. healthcare organizations. Adults with type 2 diabetes who received SGLT2i therapy were compared to those on… Continue reading #Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
#Hydrogel –elastomer-based conductive nanomembranes for soft #bioelectronics
Conformal integration of electronics with soft, irregular organ topologies remains challenging, as tissue-like platforms with bulky dimensions ranging from a few millimetres to several hundred micrometres result in incomplete signal acquisition and chronic tissue compression. Although ultrathin nanoscale devices have recently been developed to address these challenges, they involve complex and delicate handling processes that… Continue reading #Hydrogel –elastomer-based conductive nanomembranes for soft #bioelectronics
#Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
The majority of breast cancers are driven by oestrogen receptor-α (ERα) activation, and endocrine therapy represents the mainstay treatment for these patients1. However, resistance is common and tumours often progress after years of endocrine suppression2. Periodic fasting enhances the efficacy of standard endocrine therapy and delays acquired drug resistance, although the underlying mechanisms remain unclear3.… Continue reading #Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
#Cholangiocarcinoma 2026: status quo, unmet needs and priorities
Cholangiocarcinoma (CCA) is a cancer that originates within the bile ducts. Traditionally considered to be a rare neoplasm, increased awareness of CCA alongside advancements in diagnosis and the rising prevalence of certain risk factors have contributed to a global increase in incidence and mortality. CCAs are highly heterogeneous from the clinical, histomorphological and molecular perspectives… Continue reading #Cholangiocarcinoma 2026: status quo, unmet needs and priorities
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