INTRODUCTIONInvestigations of retinal biomarkers for #Alzheimer's disease (AD) and AD and related dementias (ADRD), has increased significantly. We examine retinal vascular health in a mouse containing the ADRD risk variant Mthfr677C>T to determine if changes in retina mirror similar changes in cerebrovasculature.METHODSMorphology and function of retinal vasculature and neurons were assessed using in vivo imaging,… Continue reading #Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
Tag: Retina
#Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk.Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk… Continue reading #Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
BackgroundInternational guidelines suggest screening for advanced fibrosis due to metabolic dysfunction-associated steatotic liver disease in people with type 2 diabetes, but how to implement these guidelines in clinical care remains unclear. We hypothesise that examination with VCTE could be implemented simultaneously with retina scanning with a high acceptance rate in people with type 2 diabetes.… Continue reading Screening for advanced #liver fibrosis due to metabolic dysfunction-associated #steatotic liver disease alongside #retina scanning in people with type 2 diabetes: a cross-sectional study
#Choroidal and #retinal thinning in chronic #kidney disease independently associate with eGFR decline and are modifiable with treatment
In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coherence tomography (OCT) to achieve these ends in a series of prospective studies of patients with pre-dialysis CKD (including those with a… Continue reading #Choroidal and #retinal thinning in chronic #kidney disease independently associate with eGFR decline and are modifiable with treatment
Retinal pathological features and proteome signatures of Alzheimer’s disease
Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progression in the brain remain largely unknown. To better understand the pathological features of AD in the retina, we conducted an extensive histopathological… Continue reading Retinal pathological features and proteome signatures of Alzheimer’s disease
Ocular Manifestations after Receiving COVID-19 Vaccine: A Systematic Review
The coronavirus disease 2019 (COVID-19) pandemic has had profound and lasting consequences since 2019. Although vaccines against COVID-19 have been developed and approved under emergency use authorization, various adverse events have also been reported after COVID-19 vaccination. This review was undertaken to help clinicians recognize the possible manifestations and systemic pathogenesis, especially those related to… Continue reading Ocular Manifestations after Receiving COVID-19 Vaccine: A Systematic Review
Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration
Rod and cone photoreceptors degenerate in retinitis pigmentosa (RP). While downstream neurons survive, they undergo physiological changes, including accelerated spontaneous firing in retinal ganglion cells (RGCs). Retinoic acid (RA) is the molecular trigger of RGC hyperactivity, but whether this interferes with visual perception is unknown. Here, we show that inhibiting RA synthesis with disulfiram, a… Continue reading Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration
Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a… Continue reading Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Five-Year Patterns of #Diabetic #Retinopathy Progression in US Clinical Practice
To characterize the natural course of diabetic retinopathy (DR) in contemporary clinical practice. Patients and Methods: This was a retrospective analysis of US claims data collected between January 1, 2006, and April 30, 2017. Patients aged ≥ 18 years with continuous medical and prescription insurance coverage for 18 months before DR diagnosis (index date) and… Continue reading Five-Year Patterns of #Diabetic #Retinopathy Progression in US Clinical Practice
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