Rod and cone photoreceptors degenerate in retinitis pigmentosa (RP). While downstream neurons survive, they undergo physiological changes, including accelerated spontaneous firing in retinal ganglion cells (RGCs). Retinoic acid (RA) is the molecular trigger of RGC hyperactivity, but whether this interferes with visual perception is unknown. Here, we show that inhibiting RA synthesis with disulfiram, a… Continue reading Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration
Tag: Retina
Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a… Continue reading Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Five-Year Patterns of #Diabetic #Retinopathy Progression in US Clinical Practice
To characterize the natural course of diabetic retinopathy (DR) in contemporary clinical practice. Patients and Methods: This was a retrospective analysis of US claims data collected between January 1, 2006, and April 30, 2017. Patients aged ≥ 18 years with continuous medical and prescription insurance coverage for 18 months before DR diagnosis (index date) and… Continue reading Five-Year Patterns of #Diabetic #Retinopathy Progression in US Clinical Practice
In Vivo Assessment of #Retinal Biomarkers by Hyperspectral Imaging: Early Detection of #Alzheimer’s Disease
..The retina is a developmental extension of the brain and has been viewed as a window to evaluate AD-related pathology. ..Described herein is the utilization of our retinal hyperspectral imaging (rHSI) technique as a biomarker for identification of AD-related early pathological changes in the retina The underlying principle is Rayleigh light scattering, which is expected… Continue reading In Vivo Assessment of #Retinal Biomarkers by Hyperspectral Imaging: Early Detection of #Alzheimer’s Disease
