Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive… Continue reading Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Tag: muscle
Chronic Effects of Static #Stretching Exercises on Muscle #Strength and Power in Healthy Individuals Across the Lifespan: A Systematic Review with Multi-level Meta-analysis
The current literature on the chronic effects of static stretching (SS) exercises on muscle strength and power is unclear and controversial.ObjectiveWe aimed to examine the chronic effects of SS exercises on muscle strength and power as well as flexibility in healthy individuals across the lifespan.DesignSystematic review with meta-analysis of (randomized) controlled trials.Data SourcesA systematic literature… Continue reading Chronic Effects of Static #Stretching Exercises on Muscle #Strength and Power in Healthy Individuals Across the Lifespan: A Systematic Review with Multi-level Meta-analysis
The #Quadriceps: A Physician’s In-Depth Look at a #Muscular Marvel
As a physician with a passion for human anatomy, I’ve always been intrigued by the intricacies of the human body. Today, we venture into the world of the quadriceps, a powerful group of muscles that is pivotal for movement and strength. Join me in this exploration of the anatomy and clinical relevance of the quadriceps… Continue reading The #Quadriceps: A Physician’s In-Depth Look at a #Muscular Marvel
Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
AbstractBackgroundObesity and loss of muscle mass are emerging as risk factors for dementia, but the role of adiposity infiltrating skeletal muscles is less clear. Skeletal muscle adiposity increases with older age and especially among Black women, a segment of the US population who is also at higher risk for dementia.MethodsIn 1634 adults (69–79 years, 48% women,… Continue reading Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
AbstractBackgroundImpaired muscle function has been identified as a risk factor for declining cognitive function and cardiovascular health, both of which are risk factors for late-life dementia (after 80 years of age). We examined whether hand grip strength and timed-up-and-go (TUG) performance, including their change over 5 years, were associated with late-life dementia events in older women and… Continue reading Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users
BackgroundStatin use may exacerbate exercise-induced skeletal muscle injury caused by reduced coenzyme Q10 (CoQ10) levels, which are postulated to produce mitochondrial dysfunction.ObjectivesWe determined the effect of prolonged moderate-intensity exercise on markers of muscle injury in statin users with and without statin-associated muscle symptoms. We also examined the association between leukocyte CoQ10 levels and muscle markers,… Continue reading Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
BackgroundStatin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin… Continue reading Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Potato Protein Isolate Stimulates Muscle Protein Synthesis at Rest and with Resistance Exercise in Young Women
Citation ExportAbstractSkeletal muscle myofibrillar protein synthesis (MPS) increases in response to protein feeding and to resistance exercise (RE), where each stimuli acts synergistically when combined. The efficacy of plant proteins such as potato protein (PP) isolate to stimulate MPS is unknown. We aimed to determine the effects of PP ingestion on daily MPS with and… Continue reading Potato Protein Isolate Stimulates Muscle Protein Synthesis at Rest and with Resistance Exercise in Young Women
Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 in adult mice depressed physical performance. Muscle microvascular endothelial cell apoptosis and capillary rarefaction were evident and sufficient to account for the… Continue reading Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity
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