Antimicrobial resistance (AMR) represents a significant source of morbidity and mortality worldwide, with expectations that AMR-associated consequences will continue to worsen throughout the coming decades. Since resistance to antibiotics is encoded in the microbiome, interventions aimed at altering the taxonomic composition of the gut might allow us to prophylactically engineer microbiomes that harbor fewer antibiotic… Continue reading Association of Diet and Antimicrobial Resistance in Healthy U.S. Adults
Tag: Antibiotics
Evolution of the murine gut resistome following broad-spectrum antibiotic treatment
The emergence and spread of antimicrobial resistance (AMR) represent an ever-growing healthcare challenge worldwide. Nevertheless, the mechanisms and timescales shaping this resistome remain elusive. Using an antibiotic cocktail administered to a murine model along with a longitudinal sampling strategy, we identify the mechanisms by which gut commensals acquire antimicrobial resistance genes (ARGs) after a single… Continue reading Evolution of the murine gut resistome following broad-spectrum antibiotic treatment
(844.3) Gut commensal Coprococcus comes diminishes the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors
Drug resistant HTN (rHTN) affects around 15% to 20% of hypertensive (HTN) patients. The underlying mechanisms of resistance to treatment remain poorly understood. The majority of angiotensin-converting enzyme inhibitors (ACEi) are esters, whereby we hypothesized that select gut microbiota hydrolyze ACEi rendering lower efficacy (Figure 1A). To test this hypothesis, we investigated if and which… Continue reading (844.3) Gut commensal Coprococcus comes diminishes the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors
Association of midlife antibiotic use with subsequent cognitive function in women
The gut microbiome is increasingly recognized to play a role in cognition and dementia. Antibiotic use impacts the gut microbiome and has been linked with chronic disease. Despite these data, there is no evidence supporting an association between long-term antibiotic use in adults and cognitive function. We conducted a prospective population-based cohort study among 14,542… Continue reading Association of midlife antibiotic use with subsequent cognitive function in women
Efficacy of Ceftazidime and Cefepime in the Management of COVID-19 Patients: Single Center Report from Egypt
AbstractThe purpose of this study was to explore the value of using cefepime and ceftazidime in treating patients with COVID-19. A total of 370 (162 males) patients, with RT-PCR-confirmed cases of COVID-19, were included in the study. Out of them, 260 patients were treated with cefepime or ceftazidime, with the addition of steroids to the… Continue reading Efficacy of Ceftazidime and Cefepime in the Management of COVID-19 Patients: Single Center Report from Egypt
Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea
Highlights•Antibiotic-associated diarrhea (AAD) affects a significant proportion of patients•13/30 healthy volunteers who received oral amoxicillin-clavulanate developed AAD•Individuals who developed AAD had lower levels of gut Ruminococcaceae at baseline•Baseline levels of Faecalibacterium prausnitzii were predictive of risk of AAD SummaryAntibiotic-associated diarrhea (AAD) affects a significant proportion of patients receiving antibiotics. We sought to understand if differences… Continue reading Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea
Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in ChildrenThe SCOUT-CAP Randomized Clinical Trial
Childhood community-acquired pneumonia (CAP) is usually treated with 10 days of antibiotics. Shorter courses may be effective with fewer adverse effects and decreased potential for antibiotic resistance. Objective To compare a short (5-day) vs standard (10-day) antibiotic treatment strategy for CAP in young children. Design, Setting, and Participants Randomized double-blind placebo-controlled clinical trial in outpatient… Continue reading Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in ChildrenThe SCOUT-CAP Randomized Clinical Trial
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease
Rheumatic heart disease affects more than 40.5 million people worldwide and results in 306,000 deaths annually. Echocardiographic screening detects rheumatic heart disease at an early, latent stage. Whether secondary antibiotic prophylaxis is effective in preventing progression of latent rheumatic heart disease is unknown. METHODSWe conducted a randomized, controlled trial of secondary antibiotic prophylaxis in Ugandan… Continue reading Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease
#Antibiotics Use and Subsequent Risk of #Colorectal Cancer: A Swedish Nationwide Population-Based Study
Antibiotics use may increase colorectal cancer (CRC) risk by altering the gut microbiota, with suggestive evidence reported. Our study aims to investigate antibiotics use in relation to subsequent CRC risk. MethodsThis is a nationwide, population-based study with a matched case-control design (first primary CRC cases and 5 matched, cancer-free controls). Complete-population data, extracted from Swedish… Continue reading #Antibiotics Use and Subsequent Risk of #Colorectal Cancer: A Swedish Nationwide Population-Based Study
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