Taking fewer than the widely promoted “10 000 steps per day” has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose–response relationship between steps per day and CVD can help inform clinical and public health guidelines.METHODS:Eight prospective studies (20 152… Continue reading Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis
Tag: Ageing
Age-stratified infection fatality rate of COVID-19 in the non-elderly population
The largest burden of COVID-19 is carried by the elderly, and persons living in nursing homes are particularly vulnerable. However, 94% of the global population is younger than 70 years and 86% is younger than 60 years. The objective of this study was to accurately estimate the infection fatality rate (IFR) of COVID-19 among non-elderly… Continue reading Age-stratified infection fatality rate of COVID-19 in the non-elderly population
Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality
It is known that some people age faster than others, some people live into old age disease-free, while others develop age-related chronic diseases. With a rapidly aging population and an emerging chronic diseases epidemic, finding mechanisms and implementing preventive measures that could slow down the aging process has become a new challenge for biomedical research… Continue reading Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality
Community-level age bias and older adult mortality
As the older adult population increases, understanding the health effects of bias against older adults is increasingly important. Whether structural forms of age bias predict worse health has received limited attention.ObjectiveWe hypothesized that communities with greater age bias would have higher mortality among residents aged 65 and older. We expected the association to be unique… Continue reading Community-level age bias and older adult mortality
Older adults with lower working memory capacity benefit from transcranial direct current stimulation when combined with working memory training: A preliminary study
Aging is a very diverse process: successful agers retain most cognitive functioning, while others experience mild to severe cognitive decline. This decline may eventually negatively impact one’s everyday activities. Therefore, scientists must develop approaches to counteract or, at least, slow down the negative change in cognitive performance of aging individuals. Combining cognitive training and transcranial… Continue reading Older adults with lower working memory capacity benefit from transcranial direct current stimulation when combined with working memory training: A preliminary study
Psychological resilience in older adults with type 2 diabetes from the Look AHEAD Trial
BackgroundThere is growing interest in identifying factors associated with healthy aging. This cross-sectional study evaluated associations of psychological resilience with factors associated with aging in older adults with type 2 diabetes mellitus (T2DM).MethodsParticipants were 3199 adults (72.2 ± 6.2 years of age, 61% female, 61% White, body mass index [BMI] = 34.2 ± 8.2 kg/m2) with T2DM enrolled in Look AHEAD (a multi-site… Continue reading Psychological resilience in older adults with type 2 diabetes from the Look AHEAD Trial
Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults
We have developed a deep learning aging clock using blood test data from the China Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years. We used the aging clock to demonstrate the connection between the physical and psychological aspects of aging. The clock detects accelerated aging in people with heart,… Continue reading Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults
Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults
BackgroundThe hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data.MethodsUsing a framework that combines local causal discovery algorithms with discovery of maximally predictive and compact feature sets (the “Markov boundaries” of the response)… Continue reading Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults
Motion, Relation, and Passion in Brain Physiological and Cognitive Aging
Abstract: The aim of the current paper was to present important factors for keeping the basic structures of a person’s brain function, i.e., the grey and white matter, intact. Several lines of evidence have shown that motion, relation, and passion are central factors for preserving the neural system in the grey and white matter during… Continue reading Motion, Relation, and Passion in Brain Physiological and Cognitive Aging
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