AbstractAbdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSurfer segmented 96 brain regions. Separate models segmented visceral and subcutaneous abdominal fat. Regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling… Continue reading Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals
Tag: Ageing
Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative
BackgroundAssociations of weight changes and intentionality of weight loss with longevity are not well described.MethodsUsing longitudinal data from the Women’s Health Initiative (N = 54 437; 61–81 years), we examined associations of weight changes and intentionality of weight loss with survival to ages 90, 95, and 100. Weight was measured at baseline, year 3, and year 10,… Continue reading Association of Later-Life #Weight Changes With #Survival to Ages 90, 95, and 100: The Women’s Health Initiative
Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Metformin, a first-line medication for type 2 diabetes, might also have a protective effect against ageing-related diseases, but so far little experimental evidence is available. We sought to assess the target-specific effect of metformin on biomarkers of ageing in the UK Biobank.MethodsIn this drug target mendelian randomisation study, we assessed the target-specific effect of four… Continue reading Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank
Low-Dose #Aspirin and the Risk of #Stroke and Intracerebral #Bleeding in Healthy Older People Secondary Analysis of a Randomized Clinical Trial
Low-dose aspirin has been widely used for primary and secondary prevention of stroke. The balance between potential reduction of ischemic stroke events and increased intracranial bleeding has not been established in older individuals.Objective To establish the risks of ischemic stroke and intracranial bleeding among healthy older people receiving daily low-dose aspirin.Design, Setting, and Participants This secondary analysis… Continue reading Low-Dose #Aspirin and the Risk of #Stroke and Intracerebral #Bleeding in Healthy Older People Secondary Analysis of a Randomized Clinical Trial
#Constipation Associated with #Cognitive #Aging and Decline
Key Takeaways:Chronic constipation — one bowel movement every three days or more — could signal worsening cognition.People who were chronically constipated had worse cognition equal to three years of aging, according to the study, which is the first to look at constipation’s potential impact on the aging brain.The new findings add to mounting research aligning… Continue reading #Constipation Associated with #Cognitive #Aging and Decline
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated the association between 20-year exposure to greenness [Normalized Difference Vegetation Index (NDVI)] and epigenetic aging in a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for… Continue reading Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
Hip Fractures in Institutionalized Elderly People: Incidence Rates and Excess Mortality
It is assumed that nursing homes are the setting with the highest incidence of hip fractures. This observation is, however, based on very little data. The aim of this study was to analyze hip fracture rates and the associated excess mortality in a large nursing home population. A cohort of >69,000 women and men newly… Continue reading Hip Fractures in Institutionalized Elderly People: Incidence Rates and Excess Mortality
Longer-term mixed nut consumption improves brain vascular function and memory: A randomized, controlled crossover trial in older adults
Nut consumption may reduce age-related cognitive decline, but underlying mechanisms are unclear ObjectiveTo investigate in older adults longer-term effects of mixed nut consumption on brain vascular function, which may underlie improvements in cognitive performance.MethodsTwenty-eight healthy individuals (age [mean ± SD]: 65 ± 3 years; BMI: 27.9 ± 2.3 kg/m2) were included in a randomized, single-blinded, cross-over trial with a 16-week intervention (60 g/d… Continue reading Longer-term mixed nut consumption improves brain vascular function and memory: A randomized, controlled crossover trial in older adults
Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age
Nutritional requirements for maintaining metabolic health may vary with each life stage, such as young, middle, and old age. To investigate the appropriate ratio of nutrients, particularly proteins, for maintaining metabolic health while approaching old age, young (6-month-old) and middle-aged (16-month-old) mice were fed isocaloric diets with varying protein percentages (5%, 15%, 25%, 35%, and… Continue reading Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age
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