Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.… Continue reading OXR1 maintains the retromer to delay brain #aging under #dietary restriction
The Transformative Power of Gratitude: A Journey into Presence
In the tapestry of human existence, few threads weave a narrative as profound as the essence of gratitude. Robert Holden’s timeless wisdom encapsulated in the words, “The more grateful you are, the more present you become,” unveils a profound truth that beckons us to embark on a transformative journey into the depths of mindfulness and… Continue reading The Transformative Power of Gratitude: A Journey into Presence
Consumption of 100% Fruit #Juice and Body #Weight in Children and AdultsA Systematic Review and Meta-Analysis
Importance Concerns have been raised that frequent consumption of 100% fruit juice may promote weight gain. Current evidence on fruit juice and weight gain has yielded mixed findings from both observational studies and clinical trials.Objective To synthesize the available evidence on 100% fruit juice consumption and body weight in children and adults.Data Sources MEDLINE, Embase, and Cochrane databases… Continue reading Consumption of 100% Fruit #Juice and Body #Weight in Children and AdultsA Systematic Review and Meta-Analysis
Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with systolic and diastolic blood pressure, and the risk of hypertension in a prospective 3-year longitudinal study in older adults… Continue reading Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial
The Plastic Chemicals Hiding in Your Food
By the time you open a container of yogurt, the food has taken a long journey to reach your spoon. You may have some idea of that journey: From cow to processing to packaging to store shelves. But at each step, there is a chance for a little something extra to sneak in, a stowaway of… Continue reading The Plastic Chemicals Hiding in Your Food
#ATOPIC DERMATITIS PATIENT EXPERIENCE WITH DISCUSSING AND ADDRESSING MENTAL HEALTH CONCERNS WITH ALLERGISTS
Atopic dermatitis (AD) is the most common form of eczema and has a significant, multidimensional burden of disease. Patients with AD have an increased likelihood of developing depression and anxiety, which is exacerbated when additional atopic comorbidities are present. Little is known about the patient experience with discussing or addressing mental health concerns with their… Continue reading #ATOPIC DERMATITIS PATIENT EXPERIENCE WITH DISCUSSING AND ADDRESSING MENTAL HEALTH CONCERNS WITH ALLERGISTS
#Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
BackgroundDisturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer’s disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms.ObjectiveTo explore the association between the use of lipid-lowering medications and cognitive decline over time in a cohort of patients with AD or mixed dementia with… Continue reading #Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
Febrile urinary tract infection (fUTI) in well-appearing children is conventionally treated with a standard 10-day course of oral antibiotic. The objective of this study is to determine the noninferiority (5% threshold) of a 5-day amoxicillin-clavulanate course compared with a 10-day regimen to treat fUTIs.METHODSThis is a multicenter, investigator-initiated, parallel-group, randomized, controlled trial. We randomly assigned… Continue reading Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
Effects of calibrated blue–yellow changes in light on the human #circadian clock
Evening exposure to short-wavelength light can affect the circadian clock, sleep and alertness. Intrinsically photosensitive retinal ganglion cells expressing melanopsin are thought to be the primary drivers of these effects. Whether colour-sensitive cones also contribute is unclear. Here, using calibrated silent-substitution changes in light colour along the blue–yellow axis, we investigated whether mechanisms of colour… Continue reading Effects of calibrated blue–yellow changes in light on the human #circadian clock
2 Medical News 