The lifetime risk of dementia after age 55 years was 42% (95% confidence interval: 41–43). Rates were substantially higher in women, Black adults and APOE ε4 carriers, with lifetime risks ranging from approximately 45% to 60% in these populations. The number of US adults who will develop dementia each year was projected to increase from approximately… Continue reading Lifetime risk and projected burden of #dementia
Association between recorded #physical activity and cancer progression or mortality in individuals diagnosed with #cancer in South Africa
Objectives This study aimed to determine the association between progression and mortality in individuals with stage 1 cancer and their recorded physical activity before the diagnosis of the cancer.Methods We included 28 248 members with stage 1 cancers enrolled in an oncology programme in South Africa. Physical activity was recorded using fitness devices, logged gym sessions… Continue reading Association between recorded #physical activity and cancer progression or mortality in individuals diagnosed with #cancer in South Africa
Comparison between two divergent diets, #Mediterranean and #Western, on #gut #microbiota and cognitive function in young sprague dawley rats
Clinical studies strongly suggest the importance of diet quality on cognition in youth populations (15–24 years). The Mediterranean diet (MeDi) has been shown to improve cognition in contrast to the commonly consumed Western diet (WD). The gut microbiota may serve as a mechanism for diet-induced changes in cognition. Ten-week-old male Sprague Dawley rats were assigned a… Continue reading Comparison between two divergent diets, #Mediterranean and #Western, on #gut #microbiota and cognitive function in young sprague dawley rats
Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
BackgroundTransarterial chemoembolisation (TACE) is standard care for unresectable, non-metastatic hepatocellular carcinoma. We aimed to evaluate the addition of lenvatinib and pembrolizumab to TACE versus dual placebo plus TACE in patients with unresectable, non-metastatic hepatocellular carcinoma.MethodsIn this multicentre, randomised, double-blind, phase 3 study (LEAP-012), patients were recruited from 137 global sites in 33 countries or regions.… Continue reading Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
Coffee drinking timing and mortality in US adults
Background and Aims To identify the patterns of coffee drinking timing in the US population and evaluate their associations with all-cause and cause-specific mortality.Methods This study included 40 725 adults from the National Health and Nutrition Examination Survey 1999–2018 who had complete information on dietary data and 1463 adults from the Women’s and Men’s Lifestyle… Continue reading Coffee drinking timing and mortality in US adults
The massed-spaced #learning effect in non-neural human #cells
The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived luciferase reporter controlled by a CREB-dependent promoter. We emulate training using repeated pulses of forskolin and/or phorbol ester, and, as a proxy for memory, measure luciferase expression at various… Continue reading The massed-spaced #learning effect in non-neural human #cells
Burdens of type 2 #diabetes and #cardiovascular disease attributable to sugar-sweetened beverages in 184 countries
The consumption of sugar-sweetened beverages (SSBs) is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). However, an updated and comprehensive assessment of the global burden attributable to SSBs remains scarce. Here we estimated SSB-attributable T2D and CVD burdens across 184 countries in 1990 and 2020 globally, regionally and nationally, incorporating data from the… Continue reading Burdens of type 2 #diabetes and #cardiovascular disease attributable to sugar-sweetened beverages in 184 countries
The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences depending on both the levels of antigen expression and its biological activity. A peculiarity of mRNA-based COVID-19… Continue reading The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
Membrane potential states gate #synaptic consolidation in human neocortical tissue
Synaptic mechanisms that contribute to human memory consolidation remain largely unexplored. Consolidation critically relies on sleep. During slow wave sleep, neurons exhibit characteristic membrane potential oscillations known as UP and DOWN states. Coupling of memory reactivation to these slow oscillations promotes consolidation, though the underlying mechanisms remain elusive. Here, we performed axonal and multineuron patch-clamp… Continue reading Membrane potential states gate #synaptic consolidation in human neocortical tissue
