AbstractBackground: Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer's disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any… Continue reading Higher #Coffee Consumption Is Associated With Slower #Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
Comparing Migraine Headache Index versus Monthly #Migraine Days after #Headache Surgery: A Systematic Review and Meta-Analysis
Background: Nerve deactivation surgery for the treatment of migraine has evolved rapidly over the past 2 decades. Studies typically report changes in migraine frequency (attacks/month), attack duration, attack intensity, and their composite score—the Migraine Headache Index—as primary outcomes. However, the neurology literature predominantly reports migraine prophylaxis outcomes as change in monthly migraine days (MMD). The goal… Continue reading Comparing Migraine Headache Index versus Monthly #Migraine Days after #Headache Surgery: A Systematic Review and Meta-Analysis
Clinical #EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity
Electroconvulsive therapy (ECT) is one of the most efficacious interventions for treatment-resistant depression. Despite its efficacy, ECT’s neural mechanism of action remains unknown. Although ECT has been associated with “slowing” in the electroencephalogram (EEG), how this change relates to clinical improvement is unresolved. Until now, increases in slow-frequency power have been assumed to indicate increases… Continue reading Clinical #EEG slowing induced by electroconvulsive therapy is better described by increased frontal aperiodic activity
#Sitting Time and Its Interaction With #Physical Activity in Relation to All-Cause and #Heart Disease Mortality in U.S. Adults With Diabetes
To evaluate whether associations between sitting time and all-cause and heart disease mortality are modified by physical activity in adults with diabetes.RESEARCH DESIGN AND METHODSData came from 6,335 U.S. adults with diabetes from National Health and Nutrition Examination Survey 2007–2018 (baseline), with mortality follow-up through 2019. Sitting time and moderate to vigorous physical activity (MVPA)… Continue reading #Sitting Time and Its Interaction With #Physical Activity in Relation to All-Cause and #Heart Disease Mortality in U.S. Adults With Diabetes
Brain responses to intermittent #fasting and the healthy living #diet in older adults
Highlights•8 weeks of 5:2 intermittent fasting caused more weight loss than healthy living diet•Both diets reduced neuronal insulin resistance and the pace of brain aging•Both diets improved memory and executive function, with 5:2 intermittent fasting more so•Biomarkers of Alzheimer’s disease did not change with either dietSummaryDiet may promote brain health in metabolically impaired older individuals. In… Continue reading Brain responses to intermittent #fasting and the healthy living #diet in older adults
Deep learning assists detection of #esophageal #cancer and precursor lesions in a prospective, randomized controlled study
Early-stage esophageal cancers show better treatment response but are harder to detect. Li et al. developed a deep learning pipeline to aid clinicians in identifying early-stage, high-risk esophageal lesions and tested it in a randomized clinical trial in patients undergoing endoscopy. Deep learning assistance doubled the detection of high-risk esophageal lesions compared with the unassisted control group.… Continue reading Deep learning assists detection of #esophageal #cancer and precursor lesions in a prospective, randomized controlled study
Maternal #Obesity and Risk of Sudden Unexpected Infant Death
Importance Rates of maternal obesity are increasing in the US. Although obesity is a well-documented risk factor for numerous poor pregnancy outcomes, it is not currently a recognized risk factor for sudden unexpected infant death (SUID).Objective To determine whether maternal obesity is a risk factor for SUID and the proportion of SUID cases attributable to maternal obesity.Design,… Continue reading Maternal #Obesity and Risk of Sudden Unexpected Infant Death
The effect of #anxiety on all-cause #dementia: A longitudinal analysis from the Hunter Community Study
BackgroundAnxiety is common, however, the effect of chronicity of anxiety on dementia has not been explored. This study aims to assess the longitudinal relationship between chronic versus resolved versus new onset anxiety, and all-cause dementia risk.MethodsA total of 2132 participants with mean age 76 years from the Hunter Community Study were recruited. Anxiety was measured using… Continue reading The effect of #anxiety on all-cause #dementia: A longitudinal analysis from the Hunter Community Study
#Tattoos as a risk factor for malignant #lymphoma: a population-based case–control study
BackgroundThe popularity of tattoos has increased dramatically over the last few decades. Tattoo ink often contains carcinogenic chemicals, e.g., primary aromatic amines, polycyclic aromatic hydrocarbons, and metals. The tattooing process invokes an immunologic response that causes translocation of tattoo ink from the injection site. Deposition of tattoo pigment in lymph nodes has been confirmed but the long-term… Continue reading #Tattoos as a risk factor for malignant #lymphoma: a population-based case–control study
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