artificially sweetened beverages (ASBs) ..After adjustment for BMI and initial and changes in diet and lifestyle covariates, increasing total sugary beverage intake (including both sugar-sweetened beverages and 100% fruit juices) by >0.50 serving/day over a 4-year period was associated with a 16% (95% CI 1%, 34%) higher diabetes risk in the subsequent 4 years. Increasing… Continue reading Changes in Consumption of Sugary Beverages and Artificially #Sweetened Beverages and Subsequent Risk of Type 2 #Diabetes: Results From Three Large Prospective U.S. Cohorts of Women and Men
Reducing #Suicidal Ideation Through #Insomnia Treatment (REST-IT): A Randomized Clinical Trial
..Zolpidem-CR had a robust anti-insomnia effect, especially in patients with the most severe insomnia symptoms. No significant treatment effect was observed on the Scale for Suicide Ideation (least squares mean estimate=−0.56, SE=0.83, 95% CI=−2.19, 1.08), but the reduction in scores was significantly positively related to improvement in insomnia after accounting for the effect of other… Continue reading Reducing #Suicidal Ideation Through #Insomnia Treatment (REST-IT): A Randomized Clinical Trial
Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
Highlights • Addition of fructose to a high-fat diet increases hepatic malonyl-CoA more than glucose •Knockdown of the fructose metabolizing gene ketohexokinase increases CTP1a levels •Fructose supplementation alters mitochondrial size and function •Dietary fructose induces acetylation of ACADL and CPT1a to modify fat oxidation In summary, dietary fructose, but not glucose, supplementation of HFD impairs… Continue reading Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR
People receiving their first opioid prescription were propensity matched to people receiving NSAIDS (and, in sensitivity analysis, gabapentinoids) and the risk of death and hospitalization were compared, classifying opioid medication exposure as time-varying daily oral morphine milligram equivalents (MMEs) across time-varying eGFR. Prescriptions for 1–59 and ≥60 MMEs were associated with higher risk of death… Continue reading Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR
Risk of #rhabdomyolysis with #donepezil compared with rivastigmine or galantamine: a population-based cohort study
Donepezil, rivastigmine and galantamine are popular cholinesterase inhibitors used to manage the symptoms of #Alzheimer disease and other dementias; regulatory agencies in several countries warn about a possible risk of rhabdomyolysis.. ..The average age in our 2 groups was 81.1 years, and 61.4% of our population was female. Donepezil was associated with a higher risk… Continue reading Risk of #rhabdomyolysis with #donepezil compared with rivastigmine or galantamine: a population-based cohort study
Association of Use of Oral #Contraceptives With #Depressive Symptoms Among #Adolescents and Young Women
.. adolescent users (mean [SD] age, 16.5 [0.7] years) reported higher depressive symptom scores compared with their nonusing counterparts (mean [SD] age, 16.1 [0.6] years) (mean [SD] score, 0.40 [0.30] vs 0.33 [0.30]), which persisted after adjustment for age, socioeconomic status and ethnicity (β coefficient for interaction with age, –0.021; 95% CI, –0.038 to –0.005;… Continue reading Association of Use of Oral #Contraceptives With #Depressive Symptoms Among #Adolescents and Young Women
Childhood Tobacco Smoke Exposure and Risk of Atrial #Fibrillation in Adulthood
Of 2,816 Offspring cohort participants with at least 1 parent in the Original cohort, 82% were exposed to parental smoking. For every pack/day increase in parental smoking, there was an 18% increase in offspring AF incidence (adjusted hazard ratio [HR]: 1.18; 95% confidence interval [CI]: 1.00 to 1.39; p = 0.04). Additionally, parental smoking was… Continue reading Childhood Tobacco Smoke Exposure and Risk of Atrial #Fibrillation in Adulthood
Association of Attention-Deficit/Hyperactivity Disorder With Teenage Birth Among Women and Girls in Sweden
Teenage deliveries were more common among women and girls with #ADHD than among women and girls without ADHD (15.3% vs 2.8%; odds ratio [OR], 6.23 [95% CI, 5.80-6.68]). Compared with women and girls without ADHD, those with ADHD were more likely to present with risk factors for adverse obstetric and perinatal outcomes, including smoking during… Continue reading Association of Attention-Deficit/Hyperactivity Disorder With Teenage Birth Among Women and Girls in Sweden
Associations Between Time Spent Using Social Media and Internalizing and Externalizing Problems Among US Youth
In adjusted analyses, use of social media for more than 3 hours per day compared with no use remained significantly associated with internalizing problems alone (>3 to ≤6 hours: RRR, 1.60; 95% CI, 1.11-2.31; >6 hours: RRR, 1.78; 95% CI, 1.15-2.77) and comorbid internalizing and externalizing problems (>3 to ≤6 hours: RRR, 2.01; 95% CI,… Continue reading Associations Between Time Spent Using Social Media and Internalizing and Externalizing Problems Among US Youth
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