#Coronary Artery Calcium for Personalized Allocation of #Aspirin in Primary Prevention of Cardiovascular Disease in 2019: The Multi-Ethnic Study of Atherosclerosis (MESA)

..The present study aimed to assess the value of coronary artery calcium (CAC) for guiding aspirin allocation for primary prevention using 2019 aspirin meta-analysis data on CVD relative risk reduction (RRR) and bleeding risk ..Only 5% of MESA participants would qualify for aspirin consideration for primary prevention according to ACC/AHA guidelines and using >20% estimated ASCVD risk to define “higher risk”. Benefit/harm calculations were restricted … Continue reading #Coronary Artery Calcium for Personalized Allocation of #Aspirin in Primary Prevention of Cardiovascular Disease in 2019: The Multi-Ethnic Study of Atherosclerosis (MESA)

#Aspirin for primary prevention of cardiovascular disease, part 2

..ASPREE study suggests no benefit from aspirin in primary prevention ASPREE randomized 19,114 healthy people 70 or over (65 or over for African Americans and Hispanics) to receive either 100 milligrams of enteric-coated aspirin or placebo. After an average of almost five years, there was no significant difference in the rate of fatal coronary heart disease, heart attack, stroke, or hospitalization for heart failure. There … Continue reading #Aspirin for primary prevention of cardiovascular disease, part 2

Prevalence of Human #Papillomavirus Infection by Number of Vaccine Doses Among US Women

..Compared with unvaccinated women (prevalence of 12.5% [95% CI, 9.7%-15.3%]), infection with HPV type 6, 11, 16, or 18 was significantly less prevalent among women who received 1 dose (2.4% [95% CI, 0%-4.9%]), 2 doses (5.1% [95% CI, 0.8%-9.5%]), or 3 doses (3.1% [95% CI, 0.9%-5.3%]) of HPV vaccine (Table 1). There was no significant difference in prevalence for 1 dose vs 2 doses or … Continue reading Prevalence of Human #Papillomavirus Infection by Number of Vaccine Doses Among US Women

Application of non-HDL #cholesterol for population-based #cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

..Incidence curve analyses showed progressively higher 30-year cardiovascular disease event-rates for increasing non-HDL cholesterol categories (from 7·7% for non-HDL cholesterol <2·6 mmol/L to 33·7% for ≥5·7 mmol/L in women and from 12·8% to 43·6% in men; p<0·0001). Multivariable adjusted Cox models with non-HDL cholesterol lower than 2·6 mmol/L as reference showed an increase in the association between non-HDL cholesterol concentration and cardiovascular disease for both … Continue reading Application of non-HDL #cholesterol for population-based #cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

Low‐Dose #Aspirin for Primary Prevention of #Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study

..Over a median follow‐up of 11.3 years, low‐dose aspirin use was associated with a trend toward decreased risk of ischemic cardiac death in white participants (adjusted hazard ratio: 0.86; 95% CI, 0.68–1.10), especially in women (adjusted hazard ratio: 0.72; 95% CI, 0.51–1.02), but not in black participants (adjusted hazard ratio: 1.18; 95% CI, 0.98–1.40). Similar trends were observed when the analysis was restricted to high‐risk … Continue reading Low‐Dose #Aspirin for Primary Prevention of #Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study

#Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups

..major adverse cardiovascular events (MACE) ..Aspirin use did not translate into a net clinical benefit adjusted for event-associated mortality risk (mean 0.034%; 95% CI, − 0.18 to 0.25%). There was an interaction for aspirin effect in three patient subgroups: (i) in patients under statin treatment, aspirin was associated with a 12% RRR of MACE (RR 0.88; 95% CI, 0.80–0.96), and this effect was lacking in the … Continue reading #Aspirin for primary #prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups