Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA–positive AAV and PR3-ANCA–positive AAV are increasingly recognized to have differences in genetic risk, pathogenesis, and response to treatment. Risk factors for AAV, including cigarette… Continue reading Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis
Effect of Smartphone-Enabled #Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial #Infarction
..For patients randomized to regular care, 4 physical outpatient clinic visits were scheduled in the year following the initial event. In the intervention group, patients were given 4 smartphone-compatible devices (weight scale, BP monitor, rhythm monitor, and step counter). In addition, 2 in-person outpatient clinic visits were replaced by electronic visits ..In total, 200 patients… Continue reading Effect of Smartphone-Enabled #Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial #Infarction
Can atmospheric #pollution be considered a co-factor in extremely high level of SARS-#CoV-2 lethality in Northern Italy?
This paper investigates the correlation between the high level of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) lethality and the atmospheric pollution in Northern Italy. Indeed, Lombardy and Emilia Romagna are Italian regions with both the highest level of virus lethality in the world and one of Europe’s most polluted area. Based on this correlation,… Continue reading Can atmospheric #pollution be considered a co-factor in extremely high level of SARS-#CoV-2 lethality in Northern Italy?
Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System
SARS-CoV2 host cell infection is mediated by the binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation observed in SARS-CoV was previously postulated to be due to ACE2/Ang1-7/Mas axis downregulation, increased ACE2 activity was shown to mediate disease protection. Since angiotensin II receptor blockers (ARBs), ACE inhibitors, and mineralocorticoid receptor antagonists (MRAs) increase ACE2 receptor expression,… Continue reading Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System
Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study
..A small thigh circumference is associated with an increased risk of diabetes, cardiovascular diseases, and total mortality. The purpose of this study was to evaluate the association between thigh circumference and hypertension in the middle-aged and elderly population. ..Thigh circumference was negatively correlated with systolic blood pressure, diastolic blood pressure, fasting glucose, and total cholesterol.… Continue reading Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study
#Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study
Obesity (BMI ≥ 30 kg/m2) and unfavourable lifestyle were associated with higher risk for incident type 2 diabetes regardless of genetic predisposition (p > 0.05 for GRS–obesity and GRS–lifestyle interaction). The effect of obesity on type 2 diabetes risk (HR 5.81 [95% CI 5.16, 6.55]) was high, whereas the effects of high genetic risk (HR 2.00 [95% CI 1.76,… Continue reading #Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study
Short-Term Progression of Multiterritorial Subclinical #Atherosclerosis
..Imaging detected short-term (3-year) atherosclerosis progression in 41.5% of participants (26.4% by 2DVUS, 21.3% by 3DVUS, and 11.5% by CACS), particularly in peripheral territories examined by vascular ultrasound. New atherosclerosis onset accounted for approximately one-third of total progression, also more frequently by 2DVUS and 3DVUS (29.1% and 16.6%, respectively), than by CACS (2.9%). Participants with… Continue reading Short-Term Progression of Multiterritorial Subclinical #Atherosclerosis
Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee
..We enrolled 156 patients with a mean age of 56 years; 78 patients were assigned to each group. Baseline characteristics, including severity of pain and level of disability, were similar in the two groups. The mean (±SD) baseline WOMAC scores were 108.8±47.1 in the glucocorticoid injection group and 107.1±42.4 in the physical therapy group. At… Continue reading Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee
#Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome #coronavirus 2 with high potency
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of the investigational nucleotide analogue remdesivir (RDV). RDV shows broad-spectrum antiviral activity against RNA viruses,… Continue reading #Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome #coronavirus 2 with high potency
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