..We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days.… Continue reading #Remdesivir for the Treatment of #Covid-19 — Preliminary Report
Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models
..Stable treatment response, intended as a proxy for treatment effectiveness, defined as continued prescription of an antidepressant for 90 days. Supervised topic models were used to extract 10 interpretable covariates from coded clinical data for stability prediction. With use of data from 1 hospital system (site A), generalized linear models and ensembles of decision trees… Continue reading Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models
#Hypocalcaemia predicts 12‐month re‐hospitalization in heart #failure
Potential pathophysiology of heart failure with preserved ejection fraction (HFpEF) has not been fully explored. The aim of the study was to reveal the association of serum calcium concentration at baseline with 12‐month clinical outcome in the disease.. ..Multivariate COX regression analysis revealed that baseline hypocalcaemia was associated with the increased risk of cardiac re‐hospitalization… Continue reading #Hypocalcaemia predicts 12‐month re‐hospitalization in heart #failure
Physical presence of spouse enhances brain-to-brain synchrony in co-parenting couples
Co-parenting spouses who live together remain in close physical proximity to each other and regularly engage in reciprocal social interactions in joint endeavors to coordinate their caregiving. Although bi-parental rearing is a common occurrence in humans, the influence of the physical presence of a co-parenting spouse on parental brain responses remains largely unknown. Synchrony is… Continue reading Physical presence of spouse enhances brain-to-brain synchrony in co-parenting couples
Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study
COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear.. ..Between 11 and 29 March 2020, 79 patients with IBD with COVID-19 were enrolled… Continue reading Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study
Effects of #yoga on depressive symptoms in people with mental disorders: a systematic review and meta-analysis
..Eligibility criteria for selecting studies We included randomised controlled trials with a yoga intervention comprising ≥50% physical activity in adults with a recognised diagnosed mental disorder according to DSM-3, 4 or 5. Results 19 studies were included in the review (1080 participants) and 13 studies were included in the meta-analysis (632 participants). Disorders of depression,… Continue reading Effects of #yoga on depressive symptoms in people with mental disorders: a systematic review and meta-analysis
Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
There are few primary care studies of the COVID-19 pandemic. We aimed to identify demographic and clinical risk factors for testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre primary care network.. ..We identified 3802 SARS-CoV-2 test results, of which 587… Continue reading Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
Oral #fluconazole use in the first trimester and risk of congenital #malformations: population based cohort study
..The study cohort of 1 969 954 pregnancies included 37 650 (1.9%) pregnancies exposed to oral fluconazole and 82 090 (4.2%) pregnancies exposed to topical azoles during the first trimester. The risk of musculoskeletal malformations was 52.1 (95% confidence interval 44.8 to 59.3) per 10 000 pregnancies exposed to fluconazole versus 37.3 (33.1 to 41.4) per 10 000 pregnancies exposed to… Continue reading Oral #fluconazole use in the first trimester and risk of congenital #malformations: population based cohort study
Assessment of #dextrose 50 bolus versus dextrose 10 infusion in the management of #hyperkalemia in the ED
Hypoglycemia is a common adverse effect when intravenous (IV) insulin is administered for hyperkalemia. A prolonged infusion of dextrose 10% (D10) may mitigate hypoglycemia compared to dextrose 50% (D50) bolus. Our objective was to evaluate whether D10 infusion is a safe and effective alternative to D50 bolus for hypoglycemia prevention in hyperkalemic patients receiving IV… Continue reading Assessment of #dextrose 50 bolus versus dextrose 10 infusion in the management of #hyperkalemia in the ED
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