Highlights1)Thyrotoxicosis with palpitation, and neck tenderness is the most common presentation of thyroiditis. The patients with new onset of thyrotoxicosis should be asked about history of mRNA-vaccine injection for the possible etiology. 2)mRNA vaccine induced thyroiditis could occur 10-20 days after the first dose or the second dose. 3)Management is to relieve the symptom of… Continue reading Thyroiditis after Coronavirus Disease 2019 (COVID-19) mRNA Vaccine: A Case Series
Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies
Some earlier studies reported higher risk of COVID-19 mortality in patients with vitamin D deficiency, while some others failed to find such as association. Due to inconsistences between earlier meta-analyses and needs for an updated study, we conducted current systematic review and meta-analysis on the association between vitamin D status and risk of COVID-19 in-hospital… Continue reading Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies
Frailty, lifestyle, genetics and dementia risk
To optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics. Methods We explored relationships between frailty index, healthy lifestyle and polygenic risk scores (all assessed at study entry) and incident all-cause dementia as recorded on hospital admission records and death register data. Results The analytical sample had a… Continue reading Frailty, lifestyle, genetics and dementia risk
Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series: A Danish cohort study
In this brief communication we are showing original research results with early estimates from Danish nationwide databases of vaccine effectiveness (VE) against the novel SARS-CoV-2 Omicron variant (B.1.1.529) up to five months after a primary vaccination series with the BNT162b2 or mRNA-1273 vaccines. Our study provides evidence of protection against infection with the Omicron variant… Continue reading Vaccine effectiveness against SARS-CoV-2 infection with the Omicron or Delta variants following a two-dose or booster BNT162b2 or mRNA-1273 vaccination series: A Danish cohort study
Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk
Low vitamin D status is associated with a higher risk for cardiovascular diseases (CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null effect of vitamin D on CVD risk, a non-linear effect cannot be excluded. Our aim was to apply the non-linear MR design to investigate the association of serum 25-hydroxyvitamin D… Continue reading Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk
SARS-CoV-2 Omicron VOC Transmission in Danish Households
The Omicron variant of concern (VOC) is a rapidly spreading variant of SARS-CoV-2 that is likely to overtake the previously dominant Delta VOC in many countries by the end of 2021. We estimated the transmission dynamics following the spread of Omicron VOC within Danish households during December 2021. We used data from Danish registers to… Continue reading SARS-CoV-2 Omicron VOC Transmission in Danish Households
Evaluating the number of unvaccinated people needed to exclude to prevent SARS-CoV-2 transmissions
Vaccine mandates and vaccine passports (VMVP) for SARS-CoV-2 are thought to be a path out of the pandemic by increasing vaccination through coercion and excluding unvaccinated people from different settings because they are viewed as being at significant risk of transmitting SARS-CoV-2. While variants and waning efficacy are relevant, SARS-CoV-2 vaccines reduce the risk of… Continue reading Evaluating the number of unvaccinated people needed to exclude to prevent SARS-CoV-2 transmissions
FGF1 and insulin control lipolysis by convergent pathways
Highlights•FGF1-FGFR1 signaling suppresses adipose lipolysis to curb hepatic glucose production•FGF1 suppresses lipolysis by inhibiting cAMP/PKA axis via PDE4D-S44 phosphorylation•Overexpression of PDE4D in the adipose tissue of diabetic mice corrects hyperglycemia•FGF1/PDE4D antilipolytic pathway is responsive to fed/fast states SummaryInexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes. Previously,… Continue reading FGF1 and insulin control lipolysis by convergent pathways
Impact of changing school start times on parent sleep
To examine the impact of changing school start times on sleep in parents of students in elementary, middle, and high school. MethodsAnnual surveys were completed by parents of K-12 students (n = 8190-10,592 per year) before (pre-change) and for 2 years (post-change, follow-up) after implementation of new school start times (elementary school [ES]: 60 minutes… Continue reading Impact of changing school start times on parent sleep
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