Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a known reservoir for uropathogenic bacteria, the role of the microbiota in rUTI remains unclear. We conducted a year-long study of women with (n = 15) and without (n = 16) history of rUTI, from… Continue reading Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women
Hourly Air Pollutants and Acute Coronary Syndrome Onset In 1.29 Million Patients
Short-term exposure to ambient air pollution has been linked with daily hospitalization and mortality of acute coronary syndrome (ACS); however, the associations of sub-daily (hourly) levels of criteria air pollutants with the onset of ACS and its subtypes have rarely been evaluated. Methods: We conducted a time-stratified case-crossover study among 1,292,880 ACS patients from 2,239… Continue reading Hourly Air Pollutants and Acute Coronary Syndrome Onset In 1.29 Million Patients
Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third COVID-19 wave
Cardiovascular adverse conditions are caused by coronavirus disease 2019 (COVID-19) infections and reported as side-effects of the COVID-19 vaccines. Enriching current vaccine safety surveillance systems with additional data sources may improve the understanding of COVID-19 vaccine safety. Using a unique dataset from Israel National Emergency Medical Services (EMS) from 2019 to 2021, the study aims… Continue reading Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third COVID-19 wave
Micronutrients and food choice: A case of ‘nutritional wisdom’ in humans?
Many reports show that non-human animals have the ability to select foods based on their micronutrient composition. However, it is unclear whether humans also have this ability, and researchers have lacked appropriate methods to investigate this question. In response to this challenge, we developed an approach that derives evidence from patterns of choices across a… Continue reading Micronutrients and food choice: A case of ‘nutritional wisdom’ in humans?
Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19
Risk of SARS-CoV-2 reinfection among unvaccinated people with prior COVID-19 is a subject of debate.1,2 We performed a survival analysis in a large US population to assess the degree and duration of protection associated with natural immunity in unvaccinated individuals MethodsThis cohort study used data from patients tested for SARS-CoV-2 at 1300 sites of care… Continue reading Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19
Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans
Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders and cancer. To understand the health benefits of dietary fiber supplementation, we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multiomic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel,… Continue reading Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans
SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
Background & AimsAutoimmune hepatitis episodes have been described following SARS-CoV-2 infection and vaccination but their pathophysiology remains unclear. Here, we report the case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vaccination and sought to identify the underlying immune correlates. The patient received first oral… Continue reading SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
Axial alignment is a critical regulator of knee osteoarthritis
Taking a load offOsteoarthritis (OA) is characterized by subchondral bone thickening in addition to cartilage degeneration. Here, Oláh et al. studied the role of joint alignment in OA development. Unloading the knee joint of a patient with OA with varus malalignment by high tibial osteotomy, which corrected axial malalignment, improved pain and cartilage microstructure and… Continue reading Axial alignment is a critical regulator of knee osteoarthritis
SARS-CoV-2 Naturally Acquired Immunity vs. Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: a Retrospective Cohort Study
Background: Waning of protection against infection with SARS-CoV-2 conferred by 2 doses of the BNT162b2 vaccine begins shortly after inoculation and becomes substantial within four months. With that, the impact of prior infection on incident SARS-CoV-2 reinfection is unclear. Therefore, we examined the long-term protection of naturally acquired immunity (protection conferred by previous infection) compared… Continue reading SARS-CoV-2 Naturally Acquired Immunity vs. Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: a Retrospective Cohort Study
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