RORβ modulates a gene program that is protective against articular cartilage damage

Osteoarthritis (OA) is the most prevalent chronic joint disease which increases in frequency with age eventually impacting most people over the age of 65. OA is the leading cause of disability and impaired mobility, yet the pathogenesis of OA remains unclear. Treatments have focused mainly on pain relief and reducing joint swelling. Currently there are …

Continue reading RORβ modulates a gene program that is protective against articular cartilage damage

Axial alignment is a critical regulator of knee osteoarthritis

Taking a load offOsteoarthritis (OA) is characterized by subchondral bone thickening in addition to cartilage degeneration. Here, Oláh et al. studied the role of joint alignment in OA development. Unloading the knee joint of a patient with OA with varus malalignment by high tibial osteotomy, which corrected axial malalignment, improved pain and cartilage microstructure and …

Continue reading Axial alignment is a critical regulator of knee osteoarthritis

Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

Osteoarthritis is a common condition, but curative therapies are limited. Here, Liu and colleagues developed a biodegradable scaffold using PLLA [poly(L-lactic acid)] nanofibers that when placed under applied force generated a piezoelectric charge, leading to improved chondrogenesis in vitro. Rabbits with osteochondral defects in the medial femoral condyle that were treated with the PLLA scaffold …

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Finger Joint #Cartilage Evaluated by Semiquantitative #Ultrasound Score in Patients With #Rheumatoid Arthritis

Joint destruction in rheumatoid arthritis (RA) includes both bone and cartilage lesions. Since joint space narrowing (JSN) is not a direct evaluation of cartilage using radiography, we aimed to examine the validity of ultrasound (US) cartilage evaluation using a semiquantitative method in patients with RA. Methods We enrolled 103 patients with RA who were in …

Continue reading Finger Joint #Cartilage Evaluated by Semiquantitative #Ultrasound Score in Patients With #Rheumatoid Arthritis

Effect of Intra-Articular #Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With #Osteoarthritis

..Among participants with symptomatic radiographic knee osteoarthritis, the intra-articular administration of 100 μg of sprifermin every 6 or 12 months vs placebo resulted in an improvement in total femorotibial joint cartilage thickness after 2 years that was statistically significant, but of uncertain clinical importance; there was no significant difference for 30 μg of sprifermin every …

Continue reading Effect of Intra-Articular #Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With #Osteoarthritis