To assess whether eldecalcitol, an active vitamin D analogue2, can reduce the development of type 2 diabetes among adults with impaired glucose tolerance. Design Double blinded, multicentre, randomised, placebo controlled trial. Setting Three hospitals in Japan, between June 2013 and August 2019. Participants People aged 30 years and older who had impaired glucose tolerance defined… Continue reading Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population
Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma
AbstractAsthma and inflammatory airway diseases restrict airflow in the lung, compromising gas exchange and lung function. Inhaled corticosteroids (ICSs) can reduce inflammation, control symptoms, and improve lung function; however, a growing number of patients with severe asthma do not benefit from ICS. Using bronchial airway epithelial brushings from patients with severe asthma or primary human… Continue reading Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma
The unintended consequences of COVID-19 vaccine policy: why mandates, passports and restrictions may cause more harm than good
AbstractVaccination policies have shifted dramatically during COVID-19 with the rapid emergence of population-wide vaccine mandates, domestic vaccine passports and differential restrictions based on vaccination status. While these policies have prompted ethical, scientific, practical, legal and political debate, there has been limited evaluation of their potential unintended consequences. Here, we outline a comprehensive set of hypotheses… Continue reading The unintended consequences of COVID-19 vaccine policy: why mandates, passports and restrictions may cause more harm than good
Associations between persistent organic pollutants and type 1 diabetes in youth
BackgroundDiabetes affects millions of people worldwide with a continued increase in incidence occurring within the pediatric population. The potential contribution of persistent organic pollutants (POPs) to diabetes in youth remains poorly known, especially regarding type 1 diabetes (T1D), generally the most prevalent form of diabetes in youth. ObjectivesWe investigated the associations between POPs and T1D… Continue reading Associations between persistent organic pollutants and type 1 diabetes in youth
Panic in Trudeau’s Canada as official Government figures suggest the Triple Vaccinated are developing Acquired Immunodeficiency Syndrome
Reports published by the Government of Canada strongly suggest both the triple vaccinated and double vaccinated populations across Canada are developing full blow COVID-19 vaccine-induced Acquired Immunodeficiency Syndrome (VAIDS). This is because the official figures confirm the immune systems of triple vaccinated Canadians have degraded by around 67% compared to the natural immune systems of… Continue reading Panic in Trudeau’s Canada as official Government figures suggest the Triple Vaccinated are developing Acquired Immunodeficiency Syndrome
Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis
BackgroundDebate about the level of asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection continues. The amount of evidence is increasing and study designs have changed over time. We updated a living systematic review to address 3 questions: (1) Among people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during… Continue reading Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis
To what extent does confounding explain the association between breastfeeding duration and cognitive development up to age 14? Findings from the UK Millennium Cohort Study
BackgroundBreastfeeding duration is associated with improved cognitive development in children, but it is unclear whether this is a causal relationship or due to confounding. This study evaluates whether the observed association is explained by socioeconomic position (SEP) and maternal cognitive ability. MethodsData from 7,855 singletons born in 2000–2002 and followed up to age 14 years… Continue reading To what extent does confounding explain the association between breastfeeding duration and cognitive development up to age 14? Findings from the UK Millennium Cohort Study
Varicella zoster meningitis following COVID-19 vaccination: a report of two cases
AbstractMost of the adverse effects reported in patients who have received COVID-19 vaccines have been mild. However, possible serious adverse effects are being monitored cautiously. There have also been a number of case reports of reactivation of varicella zoster infection within 28 days after immunization with mRNA COVID-19 vaccines. A few cases have also been… Continue reading Varicella zoster meningitis following COVID-19 vaccination: a report of two cases
Clustering of COPD patients and their response to pulmonary rehabilitation
Background and objectivePulmonary rehabilitation (PR) is fundamental in the management of chronic obstructive pulmonary disease (COPD). COPD patients show a large clinical heterogeneity that may influence their response to PR. Identification of homogeneous clusters of patients who may or may not respond to PR is important to personalize patient care. This study aimed at identifying… Continue reading Clustering of COPD patients and their response to pulmonary rehabilitation
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