Fructose consumption has increased considerably over the past five decades, largely due to the widespread use of high-fructose corn syrup as a sweetener1. It has been proposed that fructose promotes the growth of some tumours directly by serving as a fuel2,3. Here we show that fructose supplementation enhances tumour growth in animal models of melanoma,… Continue reading Dietary #fructose enhances #tumour growth indirectly via interorgan lipid transfer
Category: supplements
Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial
AbstractContextEvidence for a beneficial role of vitamin D on blood pressure (BP) outcomes is inconclusive.ObjectiveThis work aimed to investigate the effect of 2 doses of cholecalciferol (vitamin D3) supplementation coadministered with calcium on systolic blood pressure (SBP) and diastolic blood pressure (DBP).MethodsExploratory analyses were conducted from a 1-year, multicenter, double-blind, randomized controlled trial (RCT). Total… Continue reading Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial
Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
AbstractPrevious epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up… Continue reading Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank
Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted antigen (TRA) gene expression. Vitamin D signaling regulates Aire and TRA expression in mTECs, providing a basis for links between vitamin D deficiency and autoimmunity. We find that mice lacking Cyp27b1, which cannot… Continue reading Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
Dietary pro-oxidant therapy by a vitamin #K precursor targets PI 3-kinase VPS34 function
In light of emerging evidence that antioxidants can have cancer-promoting effects, Swamynathan et al. tested potential pro-oxidant interventions (see the Perspective by Pannia and Dowling). In particular, the authors focused on menadione sodium bisulfite, a water-soluble precursor of vitamin K. As the authors anticipated, this menadione derivative suppressed prostate cancer growth. The researchers then examined… Continue reading Dietary pro-oxidant therapy by a vitamin #K precursor targets PI 3-kinase VPS34 function
Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
The inconsistent findings concerning the effects of vitamin D supplementation on cardiometabolic risk factors and the large heterogeneity in the published literature call for further research to identify sources of heterogeneity and potential effect modifiers. We performed a meta-analysis of randomized controlled trials (RCTs) published until March 2024 that reported estimates for the effects of… Continue reading Modifiers of the Effects of Vitamin #D Supplementation on #Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development of dementia, including Alzheimer disease, may be preventable through ω-3 treatment.Objective To… Continue reading ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
The association between dietary vitamin #B1 intake and #constipation: a population-based study
BackgroundNumerous researches have indicated a correlation between the intake of dietary micronutrients and the occurrence of constipation. Nevertheless, the correlation between constipation and vitamin B1 remains uninvestigated. The main aim of this research was to examine the association between chronic constipation and the consumption of vitamin B1 in the diet among adult participants of the… Continue reading The association between dietary vitamin #B1 intake and #constipation: a population-based study
#Omega-3 supplementation reduces aggressive #behavior: A meta-analytic review of randomized controlled trials
AbstractThere is increasing interest in the use of omega-3 supplements to reduce aggressive behavior. This meta-analysis summarizes findings from 29 RCTs (randomized controlled trials) on omega-3 supplementation to reduce aggression, yielding 35 independent samples with a total of 3918 participants. Three analyses were conducted where the unit of analysis was independent samples, independent studies, and… Continue reading #Omega-3 supplementation reduces aggressive #behavior: A meta-analytic review of randomized controlled trials
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